Dua Arpita, Debnath Abhijit, Kumar Kunal, Mazumder Rupa, Mazumder Avijit, Singh Rajesh, Mangal Saloni, Sanchitra Jahanvi, Khan Fahad, Tripathi Soumya, Vishwas Sukriti, Chaudhary Hema, Sharma Parul, Srivastava Shikha
Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park-II, Institutional Area, Greater Noida-201306, Uttar Pradesh, India.
Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Curr Pharm Biotechnol. 2024 Jul 12. doi: 10.2174/0113892010305386240625072535.
Glucose monitoring is essential for managing diabetes, and continuous glucose monitoring biosensors can offer real-time monitoring with little invasiveness. However, challenges remain in improving sensor accuracy, selectivity, and overall performance. This article aims to review current trends and recent advancements in glucose-monitoring biosensors while evaluating their benefits and limitations for diabetes monitoring. An analysis of current literature on transdermal glucose sensors was conducted, focusing on detection techniques, novel nanomaterials, and integrated sensor systems. Recent research has led to advancements in electrochemical, optical, electromagnetic, and sonochemical sensors for transdermal glucose detection. The use of novel nanomaterials and integrated sensor designs has improved sensitivity, selectivity, and accuracy. However, issues like calibration requirements, motion artifacts, and skin irritation persist. Transdermal glucose sensors show promise for non-invasive, convenient diabetes monitoring but require further enhancements to address limitations in accuracy, reliability, and biocompatibility. Continued research and innovation focusing on sensor materials, designs, and surface chemistry is needed to optimize biosensor performance and utility. The study offers a comprehensive analysis of the present status of technological advancement and highlights areas that need more research.
血糖监测对于糖尿病管理至关重要，连续血糖监测生物传感器能够以几乎无创的方式提供实时监测。然而，在提高传感器的准确性、选择性和整体性能方面仍然存在挑战。本文旨在综述血糖监测生物传感器的当前趋势和最新进展，同时评估它们在糖尿病监测中的益处和局限性。对当前关于经皮葡萄糖传感器的文献进行了分析，重点关注检测技术、新型纳米材料和集成传感器系统。最近的研究推动了用于经皮葡萄糖检测的电化学、光学、电磁和声化学传感器的进展。新型纳米材料和集成传感器设计的应用提高了灵敏度、选择性和准确性。然而，校准要求、运动伪影和皮肤刺激等问题仍然存在。经皮葡萄糖传感器在无创、便捷的糖尿病监测方面显示出前景，但需要进一步改进以解决准确性、可靠性和生物相容性方面的局限性。需要持续关注传感器材料、设计和表面化学的研究与创新，以优化生物传感器的性能和实用性。该研究对技术进步的现状进行了全面分析，并突出了需要更多研究的领域。
