Evsikov E M, Liusov V A, Kharchenko V I
Kardiologiia. 1985 Jun;25(6):28-33.
Sodium, potassium and water distribution, central hemodynamic parameters, and plasma renin activity and aldosterone levels were examined in 48 patients with stable essential hypertension, including 10 males and 11 females with hypertensive crises aggravating the course of the disease, and in 18 controls. The individuals showing signs of heart and renal failure were excluded from the analysis. In female patients, the crise pattern of the disease was associated with marked changes of sodium metabolism, namely, raised extracellular fluid and plasma sodium levels, the patients with the crises having a more severe course of the disease, with higher, as compared to those of crises-free patients, total peripheral resistance and lower cardiac output values. In female patients with the crises, plasma renin activity was reduced 3.3-fold, while aldosterone levels remained unchanged, as compared to the levels of crises-free women. A direct correlation was demonstrated between the recurrence of the crises and total peripheral resistance. Causes of sodium retention in female patients with the crises are discussed.
对48例稳定型原发性高血压患者进行了钠、钾和水分布、中心血流动力学参数、血浆肾素活性和醛固酮水平的检测，其中包括10例男性和11例病情因高血压危象而加重的女性患者，并与18名对照组进行了对比。分析中排除了有心脏和肾衰竭迹象的个体。在女性患者中，疾病的危象模式与钠代谢的显著变化有关，即细胞外液和血浆钠水平升高，发生危象的患者病情更严重，与无危象患者相比，总外周阻力更高，心输出量更低。与无危象的女性相比，发生危象的女性患者血浆肾素活性降低了3.3倍，而醛固酮水平保持不变。危象的复发与总外周阻力之间存在直接相关性。文中讨论了发生危象的女性患者钠潴留的原因。
