Li Mu, Chen Liwen, Luo Zhaoxia, Yan Xiaoqin
Department of Ophthalmology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Med (Lausanne). 2024 Jun 28;11:1356839. doi: 10.3389/fmed.2024.1356839. eCollection 2024.
This study aimed to investigate and compare the anterior scleral thickness (AST) among high myopia (HM), primary open-angle glaucoma (POAG), and POAG with HM (HMPOAG) groups.
Thirty-two HM eyes, 30 POAG eyes, and 31 HMPOAG eyes were included. The Schlemm's canal (SC) area, trabecular meshwork (TM) thickness, scleral spur (SS) length, and AST were measured using swept-source optical coherence tomography. AST was measured at 0 mm (AST0), 1 mm (AST1), 2 mm (AST2), and 3 mm (AST3) from SS.
The HMPOAG group had significantly thinner AST, SS length, and TM thickness than the HM and POAG groups (all < 0.05). In addition, the SC area of the HMPOAG group was also significantly smaller than that of the HM group ( < 0.001).
The HMPOAG group had the thinnest AST, shortest SS, thinnest TM, and smallest SC. The thinnest AST might contribute to the shortest SS, and further to the thinnest TM and smallest SC in the HMPOAG group. AST might be a novel clinical indicator in the prediction and evaluation of POAG.
本研究旨在调查和比较高度近视（HM）、原发性开角型青光眼（POAG）以及高度近视合并原发性开角型青光眼（HMPOAG）组的前巩膜厚度（AST）。
纳入32只高度近视眼睛、30只原发性开角型青光眼眼睛和31只高度近视合并原发性开角型青光眼眼睛。使用扫频光学相干断层扫描测量施莱姆管（SC）面积、小梁网（TM）厚度、巩膜突（SS）长度和AST。AST在距巩膜突0毫米（AST0）、1毫米（AST1）、2毫米（AST2）和3毫米（AST3）处测量。
高度近视合并原发性开角型青光眼组的AST、SS长度和TM厚度显著薄于高度近视组和原发性开角型青光眼组（均P<0.05）。此外，高度近视合并原发性开角型青光眼组的SC面积也显著小于高度近视组（P<0.001）。
高度近视合并原发性开角型青光眼组的AST最薄、SS最短、TM最薄且SC最小。最薄的AST可能导致SS最短，进而导致高度近视合并原发性开角型青光眼组的TM最薄和SC最小。AST可能是预测和评估原发性开角型青光眼的一种新的临床指标。
