巩膜突长度对原发性开角型青光眼的诊断价值。
Diagnostic power of scleral spur length in primary open-angle glaucoma.
机构信息
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2020 Jun;258(6):1253-1260. doi: 10.1007/s00417-020-04637-4. Epub 2020 Mar 7.
PURPOSE
To investigate the diagnostic capability of scleral spur length in discriminating eyes with primary open-angle glaucoma (POAG) from healthy eyes.
METHODS
Seventy-eight eyes of 78 patients with POAG and 93 eyes of 93 age-, sex- and axial length-matched healthy subjects were included. The scleral spur length was measured using swept-source optical coherence tomography. Receiver operating characteristic (ROC) curves were derived based on the measurements.
RESULTS
The scleral spur length was significantly shorter in POAG eyes compared with healthy eyes (Method I, 164.91 ± 23.36 vs. 197.60 ± 25.32 μm; Method II, 145.15 ± 16.59 vs. 166.95 ± 19.31 μm; Method III, 162.33 ± 22.83 vs. 185.12 ± 23.58 μm, respectively; all p < 0.001). The areas under ROC curves were 0.841 (Method I), 0.810 (Method II), and 0.753 (Method III) for the scleral spur length. Moreover, Schlemm's canal area was significantly associated with the scleral spur length (Method I) in both POAG (β = 0.027; p < 0.001) and healthy (β = 0.016; p = 0.009) groups.
CONCLUSIONS
The scleral spur length had a good discriminating capability between POAG and healthy eyes, and it could be a novel biomarker for POAG evaluation clinically.
目的
研究巩膜突长度在鉴别开角型青光眼（POAG）和正常眼方面的诊断能力。
方法
纳入 78 例 POAG 患者的 78 只眼和 93 例年龄、性别和眼轴长度相匹配的健康对照者的 93 只眼。使用扫频源光学相干断层扫描测量巩膜突长度。根据测量结果绘制受试者工作特征（ROC）曲线。
结果
POAG 眼的巩膜突长度明显短于正常眼（方法 I，164.91 ± 23.36μm 比 197.60 ± 25.32μm；方法 II，145.15 ± 16.59μm 比 166.95 ± 19.31μm；方法 III，162.33 ± 22.83μm 比 185.12 ± 23.58μm，均 p<0.001）。ROC 曲线下面积分别为 0.841（方法 I）、0.810（方法 II）和 0.753（方法 III）。此外，POAG（β=0.027；p<0.001）和健康（β=0.016；p=0.009）两组中，Schlemm 管面积与巩膜突长度显著相关（方法 I）。
结论
巩膜突长度在 POAG 和正常眼之间具有良好的鉴别能力，它可能是一种评估 POAG 的新型生物标志物。
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