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水果提取物对大鼠多囊卵巢综合征的治疗作用：炎症反应和氧化应激的新作用

Therapeutic Effects of Fruit Extract on Polycystic Ovary Syndrome in a Rat Model: Emerging Role of Inflammatory Responses and Oxidative Stress.

作者信息

Dadkhah Masoomeh, Gholizadeh Negin, Nasimi Doost Azgomi Ramin, Hosseinzadeh Shahnaz, Hamedeyazdan Sanaz, Haghighat Khadijeh, Afshari Salva, Salimi Mina, Moini Jazani Arezoo

机构信息

Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.

Student Research Committee, Health School, Ardabil University of Medical Sciences, Ardabil, Iran.

出版信息

Iran J Pharm Res. 2024 Mar 9;23(1):e143290. doi: 10.5812/ijpr-143290. eCollection 2024 Jan-Dec.

DOI:10.5812/ijpr-143290
PMID:39005731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11246645/
Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disorder.

OBJECTIVES

This study evaluated the therapeutic effects of L. () fruit on pro-inflammatory cytokines, oxidative stress markers, and ovarian tissue structure in a rat model of PCOS.

METHODS

After inducing PCOS, female Wistar rats were randomly divided into control and PCOS groups. They orally received daily doses of normal saline or hydro-alcoholic extract of at two doses (200 and 400 mg/kg) for 21 days. At the end of the treatment period, ovarian and liver tissues were collected to measure lipid peroxidation, antioxidant status, TNF-α, IL-6 mRNA expression, and its content. Additionally, histopathological examinations of the ovarian tissue were conducted.

RESULTS

Our findings revealed a dose-dependent change in the biochemical and histopathological parameters. Treatment with resulted in a significant decrease in TNF-α and IL-6 mRNA expression levels and their content in the ovarian and liver tissues. It also reduced MDA levels while increasing SOD and GPx activity in both ovarian and liver tissues of PCOS rats. Furthermore, the number of follicular cysts in the PCOS rat model was significantly reduced.

CONCLUSIONS

The beneficial effects of in PCOS rats are partly attributed to the inhibition of inflammatory and oxidative stress markers in ovarian tissue. These findings suggest that could be a potential candidate for the treatment of PCOS disorders.

摘要

背景

多囊卵巢综合征（PCOS）是最常见的妇科内分泌疾病。

目的

本研究评估了L.（）果实对PCOS大鼠模型中促炎细胞因子、氧化应激标志物和卵巢组织结构的治疗效果。

方法

诱导PCOS后，将雌性Wistar大鼠随机分为对照组和PCOS组。它们每天口服生理盐水或两种剂量（200和400mg/kg）的L.（）果实水醇提取物，持续21天。在治疗期结束时，收集卵巢和肝脏组织以测量脂质过氧化、抗氧化状态、TNF-α、IL-6 mRNA表达及其含量。此外，对卵巢组织进行了组织病理学检查。

结果

我们的研究结果显示生化和组织病理学参数呈剂量依赖性变化。L.（）果实治疗导致卵巢和肝脏组织中TNF-α和IL-6 mRNA表达水平及其含量显著降低。它还降低了PCOS大鼠卵巢和肝脏组织中的MDA水平，同时增加了SOD和GPx活性。此外，PCOS大鼠模型中的卵泡囊肿数量显著减少。

结论

L.（）果实在PCOS大鼠中的有益作用部分归因于对卵巢组织中炎症和氧化应激标志物的抑制。这些发现表明L.（）果实可能是治疗PCOS疾病的潜在候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/e5323c74d357/ijpr-23-1-143290-i006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/1ae2c7e595b9/ijpr-23-1-143290-i001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/b0b611feede2/ijpr-23-1-143290-i002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/b54bf58ef787/ijpr-23-1-143290-i003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/626746137637/ijpr-23-1-143290-i004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/a278acc24e94/ijpr-23-1-143290-i005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/e5323c74d357/ijpr-23-1-143290-i006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/1ae2c7e595b9/ijpr-23-1-143290-i001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/b0b611feede2/ijpr-23-1-143290-i002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/b54bf58ef787/ijpr-23-1-143290-i003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/626746137637/ijpr-23-1-143290-i004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/a278acc24e94/ijpr-23-1-143290-i005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/11246645/e5323c74d357/ijpr-23-1-143290-i006.jpg

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Effects of natural products on polycystic ovary syndrome: From traditional medicine to modern drug discovery.天然产物对多囊卵巢综合征的影响：从传统医学到现代药物发现
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