酒精性肝病的非侵入性生物标志物——一份蛋白质组学相关初步报告。
Noninvasive Biomarkers for Alcohol-Related Liver Disease-A Proteomic Related Preliminary Report.
作者信息
Nelaturi Prabhudas, Kademani Sangeetha P, Siva Subramanian Vithiavathi, Ravikumar Sambandam
机构信息
Multi-Disciplinary Center for Biomedical Research, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to Be University), Kirumampakkam, Puducherry, 607402 India.
Department of General Medicine, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to Be University), Kirumampakkam, Puducherry, 607402 India.
出版信息
Indian J Clin Biochem. 2024 Jul;39(3):392-400. doi: 10.1007/s12291-023-01120-9. Epub 2023 Mar 3.
UNLABELLED
Increased alcohol intake over decades leads to progressive alcohol-related liver disease (ALD) and contributes to increased mortality. It is characterized by reduced platelet count. Platelets have a role in protecting vascular integrity and involved in liver regeneration. Alcohol affects the platelet count and its function. Platelet function is regulated by their proteins, released during pathophysiological conditions. Therefore, platelet proteome plays a vital role during ALD. This preliminary study consists of 10 patients with ALD. It includes the preparation of human platelets for the proteomic approach. We performed liquid chromatography-mass spectrometry for the samples. A total of 536 proteins were identified in patients with ALD of which 31 proteins were mentioned as a candidate based on their clinical significance. The advancement of diagnostic or therapeutic tools based on the application of platelet proteins in ALD is still far off. Platform for platelet and its proteome research may give diagnostic and prognostic insights into ALD. Platelet proteomes could possibly be concluded as therapeutic and potential diagnostic or prognostic markers in ALD.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s12291-023-01120-9.
未标注
数十年来酒精摄入量的增加会导致进行性酒精性肝病（ALD），并导致死亡率上升。其特征是血小板计数降低。血小板在保护血管完整性和参与肝脏再生方面发挥作用。酒精会影响血小板计数及其功能。血小板功能受其在病理生理条件下释放的蛋白质调节。因此，血小板蛋白质组在ALD过程中起着至关重要的作用。这项初步研究包括10名ALD患者。它包括为蛋白质组学方法制备人血小板。我们对样本进行了液相色谱-质谱分析。在ALD患者中总共鉴定出536种蛋白质，其中31种蛋白质根据其临床意义被列为候选蛋白。基于血小板蛋白在ALD中的应用的诊断或治疗工具的进展仍很遥远。血小板及其蛋白质组研究平台可能会为ALD提供诊断和预后见解。血小板蛋白质组可能被认为是ALD中的治疗性和潜在的诊断或预后标志物。
补充信息
在线版本包含可在10.1007/s12291-023-01120-9获取的补充材料。
Zotero 插件