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L.调节中年雌性大鼠海马中的超氧化物歧化酶和凋亡调节蛋白。

L. Modulates Superoxide Dismutase and Apoptosis-Regulating Proteins in Hippocampus of Middle-Aged Female Rats.

作者信息

Alchalidi Alchalidi, Veri Nora, Emilda Emilda, Mutiah Cut, Magfirah Magfirah, Henniwati Henniwati, Harahap Meliani Sukmadewi, Susilawati Elly

机构信息

Department of Midwifery, Midwifery Program, Aceh Polytechnic Ministry of Health-Langsa, Langsa City, Aceh, Indonesia.

Department of Nursing, Nursing Program, Aceh Polytechnic Ministry of Health-Langsa, Langsa City, Aceh, Indonesia.

出版信息

J Microsc Ultrastruct. 2022 Dec 1;12(2):71-74. doi: 10.4103/jmau.jmau_4_22. eCollection 2024 Apr-Jun.

DOI:10.4103/jmau.jmau_4_22
PMID:39006048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11245127/
Abstract

BACKGROUND AND OBJECTIVE

The aging process in women is still a problem, especially in developing countries that will become developed countries, including Indonesia. Here, we investigated the action of . extract administration on antioxidant modulation to inhibit hippocampal apoptosis in middle-aged female rats.

MATERIALS AND METHODS

Thirty-two female Wistar rats were divided into four groups ( = 8 each group): the middle-aged rats without any treatment (control group) and three . . extract groups (treated at doses of 100, 200, or 300 mg/kg b. w). The superoxide dismutase (SOD) levels and Bax and Bcl-2 expressions in the hippocampal region were analyzed using the technique of enzyme-linked immunosorbent assay.

RESULTS

The second and third doses of . . extract significantly increased the SOD hippocampal levels compared with the control ( < 0.05). This extract also decreased Bax expression (at the second and third doses) and significantly increased Bcl-2 expression (at the highest dose) than that of the control ( < 0.05).

CONCLUSIONS

The ethanol extract of . . could modulate SOD and regulate apoptotic-related proteins in middle-aged female rats. Thus, the extract of . . can be an alternative to prevent the degeneration of hippocampus due to the aging process.

摘要

背景与目的

女性衰老过程仍是一个问题，尤其在包括印度尼西亚在内的即将步入发达国家行列的发展中国家。在此，我们研究了[植物名称]提取物给药对抗氧化调节的作用，以抑制中年雌性大鼠海马体凋亡。

材料与方法

32只雌性Wistar大鼠分为四组（每组n = 8）：未经任何处理的中年大鼠（对照组）和三个[植物名称]提取物组（分别以100、200或300 mg/kg体重的剂量进行处理）。采用酶联免疫吸附测定技术分析海马区超氧化物歧化酶（SOD）水平以及Bax和Bcl-2的表达。

结果

与对照组相比，第二和第三剂量的[植物名称]提取物显著提高了海马体SOD水平（P < 0.05）。该提取物还降低了Bax表达（第二和第三剂量时），并显著提高了Bcl-2表达（最高剂量时），与对照组相比差异有统计学意义（P < 0.05）。

结论

[植物名称]乙醇提取物可调节中年雌性大鼠的SOD并调节凋亡相关蛋白。因此，[植物名称]提取物可作为预防衰老过程中海马体退化的一种替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e957/11245127/202d454ffda8/JMAU-12-71-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e957/11245127/e4d540567a23/JMAU-12-71-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e957/11245127/386aa66c1d17/JMAU-12-71-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e957/11245127/202d454ffda8/JMAU-12-71-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e957/11245127/e4d540567a23/JMAU-12-71-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e957/11245127/386aa66c1d17/JMAU-12-71-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e957/11245127/202d454ffda8/JMAU-12-71-g003.jpg

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本文引用的文献

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