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一例诊断和治疗11年后外阴黏膜侵袭性恶性黑色素瘤转移的罕见病例

A Rare Case of Invasive Malignant Melanoma Metastasis in the Vulvar Mucosa 11 Years After Diagnosis and Treatment.

作者信息

Thuremella Bhavya, Schultz Robyn, Mohan Sukanya, Castilla Maria

机构信息

General Surgery, Dr. Kiran C. Patel College of Osteopathic Medicine, NSU (Nova Southeastern University) Florida, Fort Lauderdale, USA.

General Surgery, Dr. Kiran C. Patel College of Osteopathic Medicine, NSU (Nova Southeastern University) Florida, Tampa, USA.

出版信息

Cureus. 2024 Jun 12;16(6):e62259. doi: 10.7759/cureus.62259. eCollection 2024 Jun.

Abstract

Mucosal melanoma is rare and the occurrence of an invasive malignant melanoma metastasis 11 years post-initial diagnosis is equally uncommon. This is a case of a 66-year-old woman with a history of bilateral vulvar invasive melanoma, who presented with an enlarging inguinal mass with associated tenderness upon palpation. After a right inguinal excisional lymph node biopsy, the pathological findings determined the final diagnosis as metastatic melanoma. To the best of our knowledge, this is the first report of vulvar mucosal melanoma metastasis greater than 10 years after initial diagnosis and treatment in the English language. This case discusses how treatment options for metastatic mucosal melanoma pose a challenge in such cases where follow-up for medical care is lacking. It also highlights the need for further preventative techniques and research directed towards screening techniques, staging guidelines, and treatment options for mucosal melanoma.

摘要

黏膜黑色素瘤较为罕见,在初次诊断11年后发生侵袭性恶性黑色素瘤转移的情况同样不常见。这是一例66岁女性患者,有双侧外阴侵袭性黑色素瘤病史,她因腹股沟肿物增大且触诊时有压痛前来就诊。在进行右侧腹股沟切除性淋巴结活检后,病理结果确诊为转移性黑色素瘤。据我们所知,这是英文文献中首例初次诊断和治疗10年以上后出现外阴黏膜黑色素瘤转移的报告。本病例讨论了转移性黏膜黑色素瘤的治疗方案在缺乏医疗随访的此类病例中如何构成挑战。它还强调了针对黏膜黑色素瘤的筛查技术、分期指南和治疗方案,需要进一步的预防技术和研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a559/11245045/fff36026be65/cureus-0016-00000062259-i01.jpg

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