Jia Yatian, Zhang Qian, Zhang Yihua, Wang Hui, Niu Qingmei, Zhu Ruifang, Li Jia, Fan Wen, Zhang Yuexing
Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, People's Republic of China.
School of Nursing, Shanxi University of Chinese Medicine, Jinzhong, People's Republic of China.
J Multidiscip Healthc. 2024 Jul 8;17:3167-3179. doi: 10.2147/JMDH.S471372. eCollection 2024.
Hyperlipidemia has been demonstrated to be an autonomous predictor of numerous cardiovascular and cerebrovascular ailments, and research indicates that polyphenols have preventive and therapeutic effects on hyperlipidemia. Nevertheless, the impact of polyphenol-rich foods on blood lipids and oxidative stress status in patients with hyperlipidemia remains inconclusive.
To examine the impact of polyphenol-rich foods on lipid levels and oxidative stress in individuals with hyperlipidemia.
To retrieve papers published from the establishment of the database through October 9, 2023, eight databases were searched: the Chinese National Knowledge Infrastructure, the China Biomedical Literature Database, the Wanfang Database, the China Science and Technology Journal Database, PubMed, the Cochrane Library, Embase, and the Web of Science. The quality of include studies was assessed using the Cochrane Risk of Bias in Randomized Trials tool, v2.
The study involved 13 surveys encompassing 640 patients diagnosed with hyperlipidemia. The scope of the food surveys included 12 commonly consumed food groups and medicinal and food homologous substances. All 13 studies reported the effects of polyphenol-rich foods on blood lipids, with significant improvements observed in blood lipid levels for 9 types of foods. Eight studies examined the impact on oxidative stress, and six foods demonstrated a significant reduction in oxidative stress levels. The observed effects were found to be influenced by factors such as dosage, duration of intervention, and gender.
Foods abundant in polyphenols play a crucial role in the prevention and treatment of hyperlipidemia by counteracting oxidative stress and regulating metabolic disorders. The confirmation of certain positive effects by several studies notwithstanding, discrepancies in results arise from various factors, necessitating further large-scale, prospective, well-designed randomized controlled studies to address this issue.
高脂血症已被证明是众多心脑血管疾病的独立预测因素，研究表明多酚对高脂血症具有预防和治疗作用。然而，富含多酚的食物对高脂血症患者血脂和氧化应激状态的影响仍不明确。
研究富含多酚的食物对高脂血症患者血脂水平和氧化应激的影响。
检索从数据库建立至2023年10月9日发表的论文，共检索了8个数据库：中国知网、中国生物医学文献数据库、万方数据库、维普数据库、PubMed、Cochrane图书馆、Embase和Web of Science。使用Cochrane随机对照试验偏倚风险工具v2评估纳入研究的质量。
该研究涉及13项调查，共640例被诊断为高脂血症的患者。食物调查范围包括12种常见食用食物类别以及药食同源物质。所有13项研究均报告了富含多酚的食物对血脂的影响，9种食物的血脂水平有显著改善。8项研究考察了对氧化应激的影响，6种食物的氧化应激水平显著降低。观察到的效果受剂量、干预持续时间和性别等因素影响。
富含多酚的食物通过对抗氧化应激和调节代谢紊乱，在高脂血症的预防和治疗中发挥关键作用。尽管多项研究证实了某些积极作用，但结果差异源于多种因素，有必要进一步开展大规模、前瞻性、设计良好的随机对照研究来解决这一问题。
