Fan Fangfang, Liang Zhe, Liu Zhihao, Sun Pengfei, Hu Lihua, Jia Jia, Zhang Yan, Li Jianping
Department of Cardiology, Peking University First Hospital, Beijing, People's Republic of China.
Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, People's Republic of China.
Int J Gen Med. 2024 Jul 8;17:2955-2965. doi: 10.2147/IJGM.S467320. eCollection 2024.
Early identification of new residual risk factors for coronary heart disease (CHD) is warranted. In this study, we aim to investigate the association between the serine concentration, an important amino acid in one-carbon metabolism, and CHD in Chinese hospitalized patients.
This case-control study included 428 case-control pairs comprising patients with CHD with a maximum coronary artery stenosis degree of >70% and controls with stenosis of <30%. The individuals were matched by age, sex, and date of coronary angiography at Peking University First Hospital from January 1, 2016, to December 31, 2019. Conditional logistic regression was used to investigate the associations between the serine concentration and CHD.
Patients with CHD were aged 63.48 ± 10.38 years, and 43.73% were male. Compared with controls, patients with CHD had a slightly lower serine concentration (13.35 ± 4.20 vs 13.77 ± 4.08 μg/mL), but the difference was not significant. In the multivariable conditional logistic regression analysis, for every 1 μg/mL increase in serine concentration, the odds of CHD decreased by 6% (95% confidence interval [CI] 0.90-0.99; = 0.010). Patients with a serine concentration of ≥13.41 μg/mL had a lower CHD risk than those with a serine concentration of <13.41 μg/mL (odds ratio [OR] 0.57, 95% CI 0.39-0.84; = 0.004). Subgroup analyses showed that sex interacted with the relationship between serine concentration and CHD ( = 0.039), which was more significant in males (OR 0.93, 95% CI 0.87-0.98; = 0.013) than in females.
This study observed an inverse association between the serine concentration and CHD prevalence in Chinese hospitalized patients, which revealed that serine might play a protective role in CHD.
有必要尽早识别冠心病（CHD）新的残余危险因素。在本研究中，我们旨在调查丝氨酸浓度（一碳代谢中的一种重要氨基酸）与中国住院患者冠心病之间的关联。
本病例对照研究纳入了428对病例对照，包括冠状动脉最大狭窄程度>70%的冠心病患者以及狭窄程度<30%的对照。这些个体在年龄、性别和冠状动脉造影日期方面进行了匹配，研究对象来自北京大学第一医院2016年1月1日至2019年12月31日期间的患者。采用条件逻辑回归分析来研究丝氨酸浓度与冠心病之间的关联。
冠心病患者的年龄为63.48±10.38岁，男性占43.73%。与对照组相比，冠心病患者的丝氨酸浓度略低（13.35±4.20 vs 13.77±4.08μg/mL），但差异不显著。在多变量条件逻辑回归分析中，丝氨酸浓度每增加1μg/mL，冠心病的发病几率降低6%（95%置信区间[CI]0.90 - 0.99；P = 0.010）。丝氨酸浓度≥13.41μg/mL的患者患冠心病的风险低于丝氨酸浓度<13.41μg/mL的患者（比值比[OR]0.57，95%CI 0.39 - 0.84；P = 0.004）。亚组分析显示，性别与丝氨酸浓度和冠心病之间的关系存在相互作用（P = 0.039），在男性中更为显著（OR 0.93，95%CI 0.87 - 0.98；P = 0.013），而在女性中不明显。
本研究观察到中国住院患者中丝氨酸浓度与冠心病患病率呈负相关，这表明丝氨酸可能在冠心病中发挥保护作用。
