Kim Hyun Woo, Wu Kenneth Lap Kei, Tam Kin-Wai, Chan Ying-Shing, Shum Daisy Kwok-Yan
Department of Orthopedics and Traumatology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
IBRO Neurosci Rep. 2024 Jan 3;16:147-154. doi: 10.1016/j.ibneur.2023.12.007. eCollection 2024 Jun.
Disruption of the blood-central nervous system barrier (BCB) is increasingly recognized as a pathological factor in diseases and trauma of the central nervous system. Despite the neuropathological impact, current treatment modalities do not target the BCB; strategies to reconstitute the impaired BCB have been restricted to nutritional and dietary remedies. As an integral cell type in the neurovascular unit, pericytes are crucial to the development, maintenance, and repair of the BCB. As such, pericytes are well poised as cellular agents for reconstitution of the impaired BCB. Here, we summarize recent revelations regarding the role of BCB disruption in diseases and trauma of the central nervous system and highlight how pericytes are harnessed to provide targeted therapeutic effect in each case. This review will also address how recent advances in pericyte derivation strategies can serve to overcome practical hurdles in the clinical use of pericytes.
血脑屏障（BCB）的破坏日益被认为是中枢神经系统疾病和创伤中的一个病理因素。尽管有神经病理学影响，但目前的治疗方式并未针对血脑屏障；重建受损血脑屏障的策略一直局限于营养和饮食疗法。作为神经血管单元中的一种不可或缺的细胞类型，周细胞对于血脑屏障的发育、维持和修复至关重要。因此，周细胞完全有能力作为重建受损血脑屏障的细胞因子。在此，我们总结了关于血脑屏障破坏在中枢神经系统疾病和创伤中的作用的最新发现，并强调了在每种情况下如何利用周细胞来提供靶向治疗效果。本综述还将探讨周细胞衍生策略的最新进展如何有助于克服周细胞临床应用中的实际障碍。
