Department of Periodontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Photobiomodul Photomed Laser Surg. 2024 Aug;42(8):561-567. doi: 10.1089/pho.2024.0037. Epub 2024 Jul 15.
The study aims to assess the efficacy of rose bengal (RB)-mediated antimicrobial photodynamic therapy (a-PDT) as an adjunct to scaling and root planing in the management of chronic periodontitis patients in terms of clinical parameters like gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and microbiological parameters like total microbial count, total red complex organism count, count, count, and count. In this randomized controlled clinical trial, a total of 30 patients were recruited who met the inclusion criteria. The participants were randomly allocated into group A with scaling and root planning (SRP) alone and group B with SRP + a-PDT. The clinical and microbiological parameters were measured at baseline and at 3-month follow-up. Intergroup and intragroup comparisons were performed using independent test and paired test, respectively. Value of < 0.05 was considered as statistically significant. At 3-month follow-up, group B treated with SRP + a-PDT showed statistically significant reduction in GI (0.58 ± 0.20) and PPD (1.81 ± 0.32 mm), gain in CAL (0.73 ± 0.04 mm), and reduction in total microbial count [2.80 ± 0.08 × 10 colony forming unit (CFU)], total red complex count (0.29 ± 0.14 × 10 CFU), count (0.43 ± 0.13 × 10 CFU), count (0.61 ± 0.04 × 10 CFU), and count (0.59 ± 0.04 × 10 CFU) as compared with group A ( < 0.05). RB-mediated a-PDT as an adjunct to SRP was significantly more effective in improving GI, PPD, and CAL and in reducing microbial count as compared with SRP alone in the management of chronic periodontitis.
本研究旨在评估玫瑰红 Bengal（RB）介导的光动力抗菌疗法（a-PDT）作为辅助治疗在慢性牙周炎患者中的疗效，评估指标包括临床参数（如牙龈指数[GI]、探诊袋深度[PPD]、临床附着水平[CAL]）和微生物参数（如总微生物计数、总红色复合体计数、 计数、 计数和 计数）。 在这项随机对照临床试验中，共招募了 30 名符合纳入标准的患者。将参与者随机分为单独接受龈下刮治和根面平整（SRP）的 A 组和接受 SRP+a-PDT 的 B 组。在基线和 3 个月随访时测量临床和微生物学参数。使用独立 t 检验和配对 t 检验分别进行组间和组内比较。 值<0.05 被认为具有统计学意义。 在 3 个月随访时，接受 SRP+a-PDT 治疗的 B 组 GI（0.58±0.20）和 PPD（1.81±0.32mm）显著降低，CAL（0.73±0.04mm）显著增加，总微生物计数[2.80±0.08×10 菌落形成单位（CFU）]显著降低，总红色复合体计数（0.29±0.14×10 CFU）、 计数（0.43±0.13×10 CFU）、 计数（0.61±0.04×10 CFU）和 计数（0.59±0.04×10 CFU）均显著降低，与 A 组相比（<0.05）。 与单独接受 SRP 治疗相比，RB 介导的 a-PDT 作为 SRP 的辅助治疗在改善慢性牙周炎患者的 GI、PPD 和 CAL 以及降低微生物计数方面更为有效。
