Nedumaran Nivedha, Rajasekar Arvina
Department of Periodontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.
Lasers Med Sci. 2025 Jun 25;40(1):300. doi: 10.1007/s10103-025-04548-y.
Peri-implantitis is a progressive inflammatory condition leading to bone loss around dental implants, posing challenges to implant longevity. Conventional mechanical debridement often proves insufficient due to persistent biofilms and complex implant surface morphology. This study evaluated the efficacy of rose bengal-mediated antimicrobial photodynamic therapy (a-PDT) as an adjunct to mechanical debridement in managing peri-implantitis.
A single-blinded, parallel, randomized controlled trial was conducted in the Periodontology Department of Saveetha Dental College and Hospital, Chennai. Forty-five participants diagnosed with peri-implantitis were randomly assigned into three groups: Group A (mechanical debridement alone), Group B (mechanical debridement with methylene blue-mediated a-PDT), and Group C (mechanical debridement with rose bengal-mediated a-PDT). Clinical parameters [plaque index (PI), gingival index (GI), pocket depth (PD), and crestal bone loss (CBL)], microbiological analysis (Porphyromonas gingivalis count), and biochemical analysis [interleukin-6 (IL-6) levels] were assessed at baseline and after three months. Statistical analysis was performed using ANOVA and Tukey post-hoc tests.
Group C demonstrated the most significant improvements in clinical parameters, with greater reductions in gingival index (0.59 ± 0.10; p = 0.000), pocket depth (1.87 ± 0.13 mm; p = 0.000), and crestal bone loss stability (1.68 ± 0.15; p = 0.002). Rose bengal-mediated a-PDT also achieved the highest reduction in P. gingivalis counts and IL-6 levels, with statistically significant differences compared to the other groups (p = 0.000).
Rose bengal-mediated a-PDT, combined with mechanical debridement, showed superior efficacy in managing peri-implantitis by significantly improving clinical, microbiological, and biochemical outcomes. This approach presents a promising adjunctive therapy for enhanced peri-implantitis management.
种植体周围炎是一种渐进性炎症，会导致牙种植体周围骨质流失，对种植体的长期存留构成挑战。由于生物膜持续存在以及种植体表面形态复杂，传统的机械清创术往往被证明是不够的。本研究评估了孟加拉玫瑰红介导的抗菌光动力疗法（a-PDT）作为机械清创术辅助手段治疗种植体周围炎的疗效。
在钦奈萨维塔牙科学院和医院的牙周病科进行了一项单盲、平行、随机对照试验。45名被诊断为种植体周围炎的参与者被随机分为三组：A组（仅机械清创）、B组（机械清创联合亚甲蓝介导的a-PDT）和C组（机械清创联合孟加拉玫瑰红介导的a-PDT）。在基线和三个月后评估临床参数[菌斑指数（PI）、牙龈指数（GI）、袋深（PD）和嵴顶骨吸收（CBL）]、微生物学分析（牙龈卟啉单胞菌计数）和生化分析[白细胞介素-6（IL-6）水平]。使用方差分析和Tukey事后检验进行统计分析。
C组在临床参数方面显示出最显著的改善，牙龈指数（0.59±0.10；p = 0.000）、袋深（1.87±0.13 mm；p = 0.000）和嵴顶骨吸收稳定性（1.68±0.15；p = 0.002）的降低幅度更大。孟加拉玫瑰红介导的a-PDT在牙龈卟啉单胞菌计数和IL-6水平方面也实现了最大程度的降低，与其他组相比有统计学显著差异（p = 0.000）。
孟加拉玫瑰红介导的a-PDT联合机械清创术在治疗种植体周围炎方面显示出卓越的疗效，通过显著改善临床、微生物学和生化结果。这种方法为加强种植体周围炎的管理提供了一种有前景的辅助治疗方法。
