Department of Medical Physics, Anna University, Chennai, Tamil Nadu, 600 015, India.
Department of Electronic Engineering, Gachon University, Seongnam-si 13210, Republic of Korea.
Biomater Sci. 2024 Sep 10;12(18):4727-4734. doi: 10.1039/d4bm00333k.
Sol-gel bioactive glass with nanocrystalline structures has demonstrated enhanced bioactivity and acceptance by the surrounding bone tissue. In particular, borate bioactive glasses exhibit higher reactivity and apatite formation under the simulated and conditions. This study presents a microwave-assisted synthesis of borate bioactive glass (58S) and an understanding of its structural and bioactivity. By this synthesis method, the nanocrystalline structures formed within the amorphous matrix will regulate the degradation rate of the glass network during apatite formation. The calcinated borate bioactive glass features a nanorod crystalline hydroxyapatite structure embedded in the amorphous borate glass network. The formation of apatite on the surface of borate bioactive glass within 6 hours of immersion in simulated body fluid confirms the material's enhanced bioactivity and reactivity. Anti-oxidant studies, cell viability, and alkaline phosphate activity further corroborate the bioactivity of borate bioactive glass. In summary, this study highlights the significant potential of microwave-synthesized borate bioactive glass for a wide range of bone tissue engineering applications.
具有纳米晶结构的溶胶-凝胶生物活性玻璃表现出增强的生物活性和被周围骨组织接受的能力。特别是，硼酸盐生物活性玻璃在模拟体液和生理条件下表现出更高的反应性和磷灰石形成能力。本研究提出了一种微波辅助合成硼酸盐生物活性玻璃（58S）的方法，并对其结构和生物活性进行了研究。通过这种合成方法，在非晶基质中形成的纳米晶结构将调节玻璃网络在磷灰石形成过程中的降解速率。煅烧后的硼酸盐生物活性玻璃具有纳米棒状羟基磷灰石结构，嵌入非晶态硼酸盐玻璃网络中。在模拟体液中浸泡 6 小时后，硼酸盐生物活性玻璃表面形成磷灰石，证实了该材料增强的生物活性和反应性。抗氧化研究、细胞活力和碱性磷酸酶活性进一步证实了硼酸盐生物活性玻璃的生物活性。总之，本研究强调了微波合成的硼酸盐生物活性玻璃在广泛的骨组织工程应用中的巨大潜力。
