Bengel Philipp, Sossalla Samuel, Dinov Borislav
Medizinischen Klinik I, Abteilung für Kardiologie, Universitätsklinikum Gießen, Klinikstr. 33, 35392, Gießen, Deutschland.
Abteilung Kardiologie, Kerckhoff-Klinik, Bad Nauheim, Deutschland.
Inn Med (Heidelb). 2024 Aug;65(8):770-777. doi: 10.1007/s00108-024-01744-w. Epub 2024 Jul 15.
Atrial fibrillation represents the most frequent persistent cardiac arrhythmia and is associated with an increased morbidity and mortality. An important component of the holistic treatment of atrial fibrillation is oral anticoagulation (OAC) for the prevention of stroke. The CHADS-VASc score as a risk score is recommended for estimation of the individual stroke risk and the concomitant need of OAC in these patients. In the majority of patients the OAC is nowadays carried out with direct oral anticoagulants (DOAC), which have proved to be effective with a moderate side effect profile and have replaced vitamin K antagonists as the standard substance. In the meantime, these principles have become established as the usual practice but some issues regarding OAC in patients with atrial fibrillation are still insufficiently answered. Furthermore, it is unclear whether OACs need to be continued after successful treatment of atrial fibrillation with pulmonary vein ablation or in some cases can even be discontinued. Unanswered questions also remain regarding the treatment of subclinical atrial fibrillation and atrial high-frequency episodes detected by implanted heart rhythm devices. Especially the duration of atrial high-frequency episodes that should trigger the initiation of OAC treatment is still under debate. Therefore, currently the benefits of stroke prevention must be carefully weighed up against the risk of bleeding complications.
心房颤动是最常见的持续性心律失常,与发病率和死亡率的增加相关。心房颤动整体治疗的一个重要组成部分是口服抗凝药(OAC)以预防中风。推荐使用CHADS-VASc评分作为风险评分来评估个体中风风险以及这些患者同时需要口服抗凝药的情况。如今,大多数患者使用直接口服抗凝剂(DOAC)进行口服抗凝治疗,这些药物已被证明有效且副作用适中,并且已取代维生素K拮抗剂成为标准用药。与此同时,这些原则已成为常规做法,但关于心房颤动患者口服抗凝治疗的一些问题仍未得到充分解答。此外,尚不清楚在通过肺静脉消融成功治疗心房颤动后口服抗凝药是否需要继续,或者在某些情况下甚至是否可以停用。关于植入式心律装置检测到的亚临床心房颤动和心房高频发作的治疗也存在未解决的问题。特别是应该触发口服抗凝治疗开始的心房高频发作的持续时间仍在争论中。因此,目前必须仔细权衡预防中风的益处与出血并发症的风险。