Department of Electronics and Information Systems, Faculty of Engineering and Architecture, Campus UZ Gent, Institute Biomedical Engineering and Technology (IBiTech), Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Nuclear Medicine and Molecular Imaging, KU Leuven, Louvain, Belgium.
Eur J Nucl Med Mol Imaging. 2024 Nov;51(13):3822-3839. doi: 10.1007/s00259-024-06824-5. Epub 2024 Jul 15.
The aim of this guideline is to provide recommendations for the implementation of an effective and efficient quality control (QC) programme for SPECT and PET systems in a preclinical imaging lab. These recommendations aim to strengthen the translational power of preclinical imaging results obtained using preclinical SPECT and PET. As for clinical imaging, reliability, reproducibility, and repeatability are essential when groups of animals are used in a longitudinal imaging experiment. The larger the variability of the imaging endpoint, the more animals are needed to be able to observe statistically significant differences between groups. Therefore, preclinical imaging requires quality control procedures to maintain reliability, reproducibility, and repeatability of imaging procedures, and to ensure the accuracy and precision of SPECT and PET quantification. While the Physics Committee of the European Association of Nuclear Medicine (EANM) has already published excellent procedure guidelines for Routine Quality Control Recommendations for Nuclear Medicine Instrumentation that also includes procedures for small animal PET systems, and important steps have already been made concerning preclinical quality control aspects, this new guideline provides a review and update of these previous guidelines such that guidelines are also adapted to new technological developments.
本指南的目的是为临床前成像实验室中的 SPECT 和 PET 系统提供有效的质量控制 (QC) 方案实施建议。这些建议旨在增强使用临床前 SPECT 和 PET 获得的临床前成像结果的转化能力。与临床成像一样，当在纵向成像实验中使用多组动物时，可靠性、可重复性和再现性至关重要。成像终点的变异性越大，就需要更多的动物来观察组间的统计学差异。因此，临床前成像需要质量控制程序来保持成像程序的可靠性、可重复性和再现性，并确保 SPECT 和 PET 定量的准确性和精密度。虽然欧洲核医学协会 (EANM) 的物理委员会已经发布了出色的程序指南，其中包括针对核医学仪器的常规质量控制建议程序，也包括小型动物 PET 系统的程序，并且已经在临床前质量控制方面迈出了重要的一步，但本新指南对这些先前的指南进行了审查和更新，以便使指南也适应新的技术发展。
