伊朗女性中人类乳头瘤病毒 51 型和 59 型的谱系和亚谱系分析。
Lineage and sublineage analysis of human papillomavirus types 51 and 59 in Iranian women.
机构信息
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14155, Iran.
Department of Virology, Pasteur Institute of Iran, Tehran, Iran.
出版信息
Virus Genes. 2024 Oct;60(5):455-463. doi: 10.1007/s11262-024-02089-0. Epub 2024 Jul 15.
The current study aimed to investigate the sequence variations of HPV 51 and 59 in normal cervical cells and premalignant/malignant lesions of the cervix to know the common variants of HPV 51 and HPV 59 circulating in Iran. To do this, eighty-five samples that were infected by HPV 51 or HPV 59 were investigated using hemi-PCR to amplify the E6 gene followed by sequencing. Our findings indicated that lineages A and B were detected in 80.4% and 19.6% of HPV 51-positive cases, respectively. Among samples infected with HPV 59, 32.2% belonged to lineage A and 67.8% were classified with lineage B. In conclusion, our results showed that lineage A of HPV 51 and lineage B of HPV 59 are more prevalent and distributed in Iran.
本研究旨在调查 HPV 51 和 59 在正常宫颈细胞和宫颈前病变/恶性病变中的序列变异，以了解在伊朗流行的 HPV 51 和 HPV 59 的常见变异体。为此，我们使用半巢式 PCR 扩增 E6 基因，然后进行测序，对 85 例感染 HPV 51 或 HPV 59 的样本进行了检测。我们的研究结果表明，HPV 51 阳性病例中分别检测到 A 谱系和 B 谱系占 80.4%和 19.6%。在感染 HPV 59 的样本中，32.2%属于 A 谱系，67.8%属于 B 谱系。总之，我们的研究结果表明，HPV 51 的 A 谱系和 HPV 59 的 B 谱系在伊朗更为流行和分布。
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