Sarokin L, Carlson M
Nucleic Acids Res. 1985 Sep 11;13(17):6089-103. doi: 10.1093/nar/13.17.6089.
The yeast genome contains a dispersed family of invertase structural genes (SUC1-SUC5, SUC7). Five of these genes are located very close to telomeres and are flanked by large regions of homologous sequence; recombination between telomeres could account for the dispersal of these SUC genes to different chromosomes. The SUC2 locus, in contrast, is not near a telomere and does not share large regions of flanking homology with the other loci. We examine here the relationship between SUC2 and one of the telomeric genes, SUC7. Sequence comparison revealed homology extending from about position -624 to +1791, which is close to the end of the mRNA. The 5' noncoding sequence includes two highly conserved regions: the region between -140 and +1, which contains the TATA box and presumably other promoter elements, and a second region extending from -508 to -400, which corresponds to the upstream regulatory region.
酵母基因组包含一个分散的转化酶结构基因家族（SUC1 - SUC5、SUC7）。其中五个基因位于非常靠近端粒的位置，并且两侧是大片同源序列区域；端粒之间的重组可以解释这些SUC基因分散到不同染色体上的现象。相比之下，SUC2基因座不在端粒附近，并且与其他基因座没有大片侧翼同源区域。我们在此研究SUC2与其中一个端粒基因SUC7之间的关系。序列比较显示同源性从大约 - 624位延伸到 + 1791位，这接近mRNA的末端。5'非编码序列包括两个高度保守的区域：- 140到 + 1之间的区域，其中包含TATA盒以及大概其他启动子元件，以及从 - 508延伸到 - 400的第二个区域，该区域对应于上游调控区域。
