From the Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China (KZ, FZ, SW, YZ, QC, HY); and Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Guangzhou, Guangdong Province, China (KZ, FZ, SW, YZ, QC, HY).
J Occup Environ Med. 2024 Nov 1;66(11):867-873. doi: 10.1097/JOM.0000000000003188. Epub 2024 Jul 8.
The aim of the study is to explore the feasibility of using nonvibration-exposed organ-related indices as vibration-induced white finger (VWF) diagnostic biomarkers.
Individuals were selected from a factory in China using the judgment sampling method. They were divided into control (con), non-VWF, and VWF groups according to the presence/absence of exposure to hand-transmitted vibration and VWF. Blood samples were collected for ELISA tests.
Analysis of receiver operating characteristic curves was done on six indicators to assess their diagnostic sensitivity for VWF. Area under the receiver operating characteristic curve for insulin was 0.909 and was 0.923 for aspartate aminotransferase.
Insulin and aspartate aminotransferase could be used as indices for the diagnosis of hand-arm vibration syndrome.
本研究旨在探讨使用非振动暴露器官相关指标作为振动性白指（VWF）诊断生物标志物的可行性。
采用判断抽样法从中国某工厂中选取研究对象，根据是否接触手部传振和 VWF 将其分为对照组（con）、非 VWF 组和 VWF 组，并采集血样进行 ELISA 检测。
对 6 项指标进行受试者工作特征曲线分析，评估其对 VWF 的诊断灵敏度。胰岛素的受试者工作特征曲线下面积为 0.909，天冬氨酸转氨酶为 0.923。
胰岛素和天冬氨酸转氨酶可作为诊断手臂振动病的指标。
