From the School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China; and Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Guangdong Pharmaceutical University, Guangzhou, China.
J Occup Environ Med. 2023 Dec 1;65(12):1070-1076. doi: 10.1097/JOM.0000000000002957. Epub 2023 Sep 1.
Purposes of this study are to study the changes in expression of vascular regulators after vibration exposure and during the onset of vibration-induced white finger (VWF) and to screen for vascular regulatory factors that could be used as early biomarkers of HAVS.
Using judgmental sampling from a Chinese factory, workers with VWF and hand-transmitted vibration exposure but without VWF were selected for research. Blood samples were taken from all subjects, and the levels of nine of the vascular regulators were measured using ELISA.
Receiver operating characteristic curve analysis was performed on nine vascular regulators to assess their diagnostic sensitivity for VWF with the following area under the curve results: PGI 2 = 0.861, ANP = 0.840.
Collectively, PGI 2 and ANP exhibited the most potential for the early diagnosis of HAVS.
本研究旨在探讨振动暴露后及振动性白指（VWF）发作期间血管调节因子表达的变化，并筛选出可作为职业性手臂振动病（HAVS）早期生物标志物的血管调节因子。
采用判断抽样法，从一家中国工厂中选择患有 VWF 且手部接触振动暴露但无 VWF 的工人作为研究对象。采集所有受试者的血样，采用 ELISA 法测定 9 种血管调节因子的水平。
对 9 种血管调节因子进行受试者工作特征曲线分析，以评估其对 VWF 的诊断灵敏度，结果如下：PGI 2 = 0.861，ANP = 0.840。
PGI 2 和 ANP 对 HAVS 的早期诊断最具潜力。
