Ganie Mohd Ashraf, Chowdhury Subhankar, Suri Vanita, Joshi Beena, Bhattacharya Prasanta Kumar, Agrawal Sarita, Malhotra Neena, Sahay Rakesh, Jabbar Puthiyaveettil Khadar, Rozati Roya, Bashir Rohina, Roshan Reshma, Wani Imtiyaz, Rashid Haroon, Meshram Gaivee, Choudhury Shouvik, Shukla Amlin, Arora Taruna
Department of Endocrinology, and Clinical Research, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, India.
Department of Endocrinology and Metabolism, Institute of Postgraduate Medical Education & Research, Kolkata, India.
Indian J Hematol Blood Transfus. 2024 Jul;40(3):479-486. doi: 10.1007/s12288-023-01714-6. Epub 2023 Nov 20.
Despite the negative implications on women's health, pregnancy, and fetal outcomes, population-based studies on hematological indices among reproductive age women in India have received inadequate attention. This study aimed to generate normative ranges for various hematological parameters among these women. After ethics approval, apparently healthy (n = 5884) women (aged 18-40 years) were recruited from six eco-geographic zones of India. After various exclusions (n = 5412), including women having anemia, data of clinically, and biochemically healthy women (n = 472) was analysed to generate centiles (2.5 and 97.5th) and correlations. The mean age and mean BMI of women was 29.3 ± 6.5 years and 23.25 ± 3.26 kg/m with BP of 112.26 ± 8.9/74.04 ± 6.7 mmHg. The reference intervals for hemoglobin (12-15.1 gm/dl), RBC (3.68-5.55 millions/μl), WBC (4.1-11.26109/L), platelet count (1.32-4.42105/μl), and erythrocyte sedimentation rate (4.35-41.65 mm/hr) were different from currently used reference values ( < 0.05). However, these haematological indices did not vary among various age categories, geographical zones, ethnicities and rural or urban origins. Pearson's correlation revealed a statistically significant association between ESR, WBC, monocytes, and platelets with homeostasis model assessment of insulin resistance (HOMA-IR). Women with HOMA-IR > 2 displayed a statistically significant differences in parameters like MCV, ESR, eosinophil and platelet counts as compared to the women with HOMA-IR < 2. This study provides a pioneering reference data of hematological indices among women of reproductive age in India. Despite the small sample size results can be extrapolated to the national population given the representative sampling of various geographical zones. This may pave way for future comprehensive large-scale studies on the subject.
The online version contains supplementary material available at 10.1007/s12288-023-01714-6.
尽管对女性健康、妊娠和胎儿结局有负面影响，但印度针对育龄女性血液学指标的基于人群的研究却未得到充分关注。本研究旨在得出这些女性各种血液学参数的正常范围。经伦理批准后，从印度六个生态地理区域招募了表面健康的（n = 5884）18至40岁女性。在进行各种排除（n = 5412），包括排除患有贫血的女性后，对临床和生化指标健康的女性（n = 472）的数据进行分析，以得出百分位数（第2.5和第97.5百分位数）及相关性。女性的平均年龄和平均体重指数分别为29.3±6.5岁和23.25±3.26kg/m²，血压为112.26±8.9/74.04±6.7mmHg。血红蛋白（12 - 15.1g/dl）、红细胞（3.68 - 555万/μl）、白细胞（4.1 - 11.26×10⁹/L）、血小板计数（1.32 - 4.42×10⁵/μl）以及红细胞沉降率（4.35 - 41.65mm/hr）的参考区间与目前使用的参考值不同（P < 0.05）。然而，这些血液学指标在不同年龄类别、地理区域、种族以及农村或城市来源之间并无差异。皮尔逊相关性分析显示，红细胞沉降率、白细胞、单核细胞和血小板与胰岛素抵抗的稳态模型评估（HOMA - IR）之间存在统计学上的显著关联。与HOMA - IR < 2的女性相比，HOMA - IR > 2的女性在平均红细胞体积、红细胞沉降率、嗜酸性粒细胞和血小板计数等参数上存在统计学上的显著差异。本研究提供了印度育龄女性血液学指标的开创性参考数据。尽管样本量较小，但鉴于对不同地理区域的代表性抽样，结果可外推至全国人口。这可能为该主题未来的全面大规模研究铺平道路。
在线版本包含可在10.1007/s12288 - 023 - 01714 - 6获取的补充材料。
