Antimicrobial peptide-fibrin glue mixture for treatment of methicillin-resistant -infected wounds.

This study was conducted to investigate the effect of fibrin glue-CM11 antibacterial peptide mixture (FG-P) on the healing of infected wounds . We formulated a mixture of FG-P and evaluated its antimicrobial activity against multidrug-resistant (MDR) bacteria involved in wound infection as well as its healing effect on wound infected by methicillin-resistant (MRSA) . The peptide had an MIC of 8 μg/ml against all bacteria isolates. Growth inhibition zones were evident for FG-P compared with FG. The study showed that the FG-P could be significantly effective in healing the MRSA-infected wound. The use of FG-P mixture is a very suitable option for treating infected wounds.