Juhasz Bertalan, Cuesta Angel, Howe Russell F, Jaspars Marcel
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Building, Aberdeen AB24 3UE, Scotland, UK.
Advanced Centre for Energy and Sustainability (ACES), Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, Scotland, UK.
Org Biomol Chem. 2024 Jul 31;22(30):6156-6165. doi: 10.1039/d4ob00816b.
Dermacozines, the secondary metabolites of the Mariana Trench sediment bacterium MT1.1, were studied using cyclic voltammetry (CV), electron paramagnetic resonance (EPR), furthermore literature and own experimental UV-Vis spectroscopic data. With those measurements, we determined experimentally the positions of the HOMO, which shifts towards more positive potentials, and the constant LUMO on the standard hydrogen electrode scale, while the HOMO-LUMO gap gets deeper, respectively. The HOMO energies of dermacozines experimentally were proven to be water oxidising. EPR spectroscopy demonstrated the formation of semiquinone radicals in the case of dermacozines E and O upon irradiation with visible light corresponding to the absorption maxima (AM) of the chromophores. Our findings suggest that the dermacozines may assist the strain by maintaining redox homeostasis through its respiratory chain.
利用循环伏安法（CV）、电子顺磁共振（EPR），以及文献和自身实验的紫外-可见光谱数据，对马里亚纳海沟沉积物细菌MT1.1的次生代谢产物——皮马菌素进行了研究。通过这些测量，我们实验确定了最高占据分子轨道（HOMO）的位置（其向更正的电位移动）以及在标准氢电极标度上恒定的最低未占分子轨道（LUMO），而HOMO-LUMO能隙则分别变深。实验证明，皮马菌素的HOMO能量具有水氧化作用。电子顺磁共振光谱表明，在皮马菌素E和O用对应于发色团吸收最大值（AM）的可见光照射时会形成半醌自由基。我们的研究结果表明，皮马菌素可能通过其呼吸链维持氧化还原稳态来协助该菌株。
