从马里亚纳海沟沉积物中分离得到的深海菌株 Dermacoccus abyssi 中分离得到 Dermacozines H-J。

Dermacozines H-J isolated from a deep-sea strain of Dermacoccus abyssi from Mariana Trench sediments.

机构信息

Mikrobiologisches Institut, Universität Tübingen , Auf der Morgenstelle 28, 72076 Tübingen, Germany.

出版信息

J Nat Prod. 2014 Feb 28;77(2):416-20. doi: 10.1021/np400952d. Epub 2014 Feb 5.

Abstract

Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of 1D and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 μM.

摘要

深海糖多孢菌（Dermacoccus abyssi）MT1.1 和 MT1.2 株是从马里亚纳海沟沉积物中分离得到的放线菌，深度为 10898 米。使用复杂培养基的发酵过程导致产生了三种新型色素杂芳族（氧化和还原）吩嗪化合物，即 dermacozines H-J（1-3）。广泛使用 1D 和 2D NMR 实验和高分辨率 MS 来确定化合物的结构。新型 dermacozines 显示出自由基清除活性，并且 dermacozine H（1）表现出最高的活性，IC50 值为 18.8 μM。