Zheng Qiao, Zhao Jin, Yuan Jinguo, Qin Yunlong, Zhu Zhanxin, Liu Jie, Sun Shiren
Department of Postgraduate Student, Xi'an Medical University, Xi'an, China.
Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Aging Dis. 2024 Jun 6;16(3):1397-1413. doi: 10.14336/AD.2024.0168.
Given the rapid aging of the population, age-related diseases have become an excessive burden on global health care. The kidney, a crucial metabolic organ, ages relatively quickly. While the aging process itself does not directly cause kidney damage, the physiological changes that accompany it can impair the kidney's capacity for self-repair. This makes aging kidneys more susceptible to diseases, including increased risks of chronic kidney disease and end-stage renal disease. Therefore, delaying the progression of renal aging and preserving the youthful vitality of the kidney are crucial for preventing kidney diseases. However, effective strategies against renal aging are still lacking due to the underlying mechanisms of renal aging, which have not been fully elucidated. Accumulating evidence suggests that metformin has beneficial effects in mitigating renal aging. Metformin has shown promising anti-aging results in animal models but has not been tested for this purpose yet in clinical trials. These findings indicate the potential of metformin as an anti-renal aging drug. In this review, we primarily discuss the characteristics and mechanisms of kidney aging and the potential effects of metformin against renal aging.
鉴于人口的迅速老龄化，与年龄相关的疾病已成为全球医疗保健的沉重负担。肾脏作为一个重要的代谢器官，衰老相对较快。虽然衰老过程本身不会直接导致肾脏损伤，但伴随衰老而来的生理变化会损害肾脏的自我修复能力。这使得衰老的肾脏更容易患上疾病，包括慢性肾脏病和终末期肾病的风险增加。因此，延缓肾脏衰老的进程并保持肾脏的年轻活力对于预防肾脏疾病至关重要。然而，由于肾脏衰老的潜在机制尚未完全阐明，目前仍缺乏有效的抗肾脏衰老策略。越来越多的证据表明，二甲双胍在减轻肾脏衰老方面具有有益作用。二甲双胍在动物模型中已显示出有前景的抗衰老效果，但尚未针对此目的在临床试验中进行测试。这些发现表明二甲双胍作为一种抗肾脏衰老药物的潜力。在本综述中，我们主要讨论肾脏衰老的特征和机制以及二甲双胍对肾脏衰老的潜在影响。
