Kennedy M J, Volz P A
Sabouraudia. 1985 Aug;23(4):265-73. doi: 10.1080/00362178585380391.
Mice were treated orally with various antibiotics to determine which members of the indigenous intestinal microflora normally suppress Candida albicans colonization and dissemination from the gastrointestinal (GI) tract. The mice were given penicillin, clindamycin, vancomycin, erythromycin, or gentamicin for 3 days, and then challenged orally with C. albicans. Penicillin, clindamycin, and vancomycin, but not gentamicin or erythromycin, decreased the total anaerobic bacterial populations in the animals ceca, and increased the enteric bacilli population levels. All three of the former antibiotics allowed C. albicans to proliferate in the gut and, subsequently, disseminate from the GI tract to visceral organs. The ability of C. albicans to associate with intestinal mucosal surfaces was also tested. It was found that antibiotics which reduced anaerobic population levels, but not enteric bacilli or aerobes, also predisposed animals to mucosal association by C. albicans. It is suggested that the strictly anaerobic bacterial populations which predominate in the gut ecosystem are responsible for the inhibition of C. albicans adhesion, colonization and dissemination from the GI tract.
给小鼠口服各种抗生素，以确定肠道内正常抑制白色念珠菌在胃肠道（GI）定植和扩散的微生物群落成员。给小鼠服用青霉素、克林霉素、万古霉素、红霉素或庆大霉素3天，然后口服白色念珠菌进行挑战。青霉素、克林霉素和万古霉素（而非庆大霉素或红霉素）降低了动物盲肠中的总厌氧菌数量，并提高了肠道杆菌的数量水平。前三种抗生素均使白色念珠菌在肠道中增殖，并随后从胃肠道扩散至内脏器官。还测试了白色念珠菌与肠道黏膜表面结合的能力。结果发现，降低厌氧菌数量水平但不影响肠道杆菌或需氧菌数量的抗生素，也使动物易于发生白色念珠菌与黏膜的结合。研究表明，在肠道生态系统中占主导地位的严格厌氧菌群体负责抑制白色念珠菌从胃肠道的黏附、定植和扩散。
