Kennedy M J, Volz P A
Sabouraudia. 1983 Mar;21(1):27-33. doi: 10.1080/00362178385380051.
Mice pretreated with antibiotics were inoculated intragastrically with different yeast isolates to determine whether the resulting disruption of the normal flora ecology would allow certain fungi to colonize and disseminate from the gastrointestinal tract. Antibiotic treatment decreased the total population levels of the indigenous bacterial flora, and predisposed mice to gastrointestinal overgrowth and subsequent dissemination by Candida albicans, C. parapsilosis, C. pseudotropicalis, C. tropicalis, and Torulopsis glabrata. A clinical isolate of Rhodotorula rubra, on the other hand, was unable to maintain a stable population in the gut of similar mice and could not be isolated from systemic organs. Control animals not receiving antibiotic therapy, challenged with C. albicans, showed significantly lower gut population levels of yeasts, and Candida organisms could not be grown from visceral organs. It is suggested that suppression of fungi within the gastrointestinal tract by members of the normal bacterial flora may be an important mechanism whereby fungi are confined to the alimentary tract.
用抗生素预处理的小鼠经胃内接种不同的酵母分离株，以确定由此导致的正常菌群生态破坏是否会使某些真菌在胃肠道定植并播散。抗生素治疗降低了本土细菌菌群的总体水平，并使小鼠易发生胃肠道过度生长，随后白色念珠菌、近平滑念珠菌、伪热带念珠菌、热带念珠菌和光滑球拟酵母菌得以播散。另一方面，一株深红酵母临床分离株在类似小鼠的肠道中无法维持稳定的种群数量，且无法从全身器官中分离出来。未接受抗生素治疗的对照动物在受到白色念珠菌攻击后，肠道酵母种群水平显著降低，且在内脏器官中无法培养出念珠菌。提示正常细菌菌群成员对胃肠道内真菌的抑制可能是将真菌限制在消化道内的重要机制。
