College of Nursing, Florida State University, Tallahassee, Florida, USA
College of Nursing, Florida State University, Tallahassee, Florida, USA.
BMJ Open. 2024 Jul 16;14(7):e082988. doi: 10.1136/bmjopen-2023-082988.
COVID-19 vaccination is crucial for vulnerable people with underlying chronic conditions such as Alzheimer's disease and related dementias (ADRD) and mild cognitive impairment (MCI). These individuals face unique challenges, including higher risk of COVID-19, difficulties in adopting preventive behaviours and vaccine hesitancy due to concerns about adverse reactions. Therefore, efforts to promote vaccination, including boosters tailored to the currently circulating virus, are essential for people with ADRD/MCI.
The primary purpose of this study protocol is to conduct a comprehensive analysis of COVID-19 vaccination coverage and adverse reactions among individuals with ADRD/MCI in comparison to those without ADRD/MCI. Additionally, the proposed study aims to investigate the impact of social determinants of health on COVID-19 vaccination and vaccine hesitancy in individuals with ADRD/MCI.
A retrospective cross-sectional study will be conducted utilising data from the ) Researcher Workbench. Relevant data fields are extracted from sources including demographic information, COVID-19 Vaccine Survey, Basic Survey, Health Access & Utilization, Social Determinants of Health, and Electronic Health Record (EHR) data. Data on vaccination, adverse reactions and vaccine hesitancy will be collected through COVID-19 vaccine survey questionnaires. Propensity score matching and binary logistic regression will be applied to assess the vaccination rates and vaccine hesitancy, while controlling for demographic characteristics and social determinants of health factors.
This study protocol received approval from the Institutional Review Board at Florida State University (STUDY00004571). Results will be disseminated through publication in peer-reviewed journals and presented at scientific conferences.
对于患有阿尔茨海默病及相关痴呆症（ADRD）和轻度认知障碍（MCI）等潜在慢性疾病的脆弱人群而言，接种 COVID-19 疫苗至关重要。这些人面临着独特的挑战，包括感染 COVID-19 的风险更高、难以采取预防措施，以及由于担心不良反应而对接种犹豫不决。因此，为 ADRD/MCI 患者推广疫苗接种，包括针对当前流行病毒的加强针，是必不可少的。
本研究方案的主要目的是全面分析患有 ADRD/MCI 个体与无 ADRD/MCI 个体的 COVID-19 疫苗接种率和不良反应情况。此外，本研究旨在探讨健康的社会决定因素对 ADRD/MCI 患者 COVID-19 疫苗接种和疫苗犹豫的影响。
本研究将采用回顾性横断面研究设计，利用来自 ) Researcher Workbench 的数据进行。从人口统计学信息、COVID-19 疫苗调查、基础调查、健康获取与利用、健康的社会决定因素以及电子健康记录（EHR）数据等来源中提取相关数据字段。通过 COVID-19 疫苗调查问卷收集疫苗接种、不良反应和疫苗犹豫的数据。将采用倾向评分匹配和二元逻辑回归来评估疫苗接种率和疫苗犹豫情况，同时控制人口统计学特征和健康的社会决定因素。
本研究方案已获得佛罗里达州立大学机构审查委员会的批准（STUDY00004571）。研究结果将通过在同行评议期刊上发表和在科学会议上展示来传播。
