Departments of Pediatrics and Neonatology, Dana Dwek Children's Hospital, Tel Aviv Medical Center, Tel Aviv, Israel.
Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Perinatol. 2024 Nov;44(11):1607-1610. doi: 10.1038/s41372-024-02057-4. Epub 2024 Jul 16.
We aimed to systematically review articles that reported selenium (Se) concentrations in human milk (HM).
using PRISMA guidelines we searched MEDLINE and Embase using the terms "human milk and Selenium". All clinical trials and systematic reviews were retrieved.
Out of 1141 articles, we reviewed 76 full-text articles, excluding 26. Thus, 50 articles were included in meta-analyses. Most studies (N = 31) did not specify whether milk was from mothers of preterm (PT) or fullterm (T) infants. In the other 19 studies, 1 examined PT-EHM, 15 T-EHM, and 3 both PT-EHM and T-EHM. In most studies, Se concentrations were highest in colostrum or until 3 months of lactation, then declined. Metaanalyzed means of PT-EHM or T-EHM provide estimates of Se intake a little higher than those reported to date, but still lower than current recommendations of intake.
This study provides clinicians with useful estimates of Se intake in breast-fed infants.
本研究旨在系统地回顾报道人乳中硒（Se）浓度的文献。
本研究按照 PRISMA 指南，使用“人乳和硒”这两个术语，检索了 MEDLINE 和 Embase 中的文章。所有的临床试验和系统评价都被检索到。
在 1141 篇文章中，我们查阅了 76 篇全文文章，排除了 26 篇，因此，50 篇文章被纳入荟萃分析。大多数研究（N=31）没有具体说明母乳是来自早产儿（PT）还是足月儿（T）母亲。在其他 19 项研究中，有 1 项研究检查了 PT 母乳，15 项研究检查了 T 母乳，3 项研究同时检查了 PT 母乳和 T 母乳。在大多数研究中，Se 浓度在初乳或哺乳期前 3 个月最高，然后下降。荟萃分析得出的 PT-EHM 或 T-EHM 的平均值提供了比目前报道的稍高的 Se 摄入量估计值，但仍低于目前推荐的摄入量。
本研究为临床医生提供了有用的母乳喂养婴儿 Se 摄入量估计值。
