Department of Exercise Physiology, Faculty of Sport Sciences, Bu-Ali Sina University, Hamedan, Iran.
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
J Physiol Sci. 2024 Jul 16;74(1):36. doi: 10.1186/s12576-024-00925-4.
Exercise increases the pain threshold in healthy people. However, the pain threshold modulation effect of exercise and hawthorn is unclear because of its potential benefits in people with persistent pain, including those with Alzheimer's disease. Accordingly, after the induction of Alzheimer's disease by trimethyl chloride, male rats with Alzheimer's disease were subjected to a 12-week training regimen consisting of resistance training, swimming endurance exercises, and combined exercises. In addition, hawthorn extract was orally administered to the rats. Then, their pain threshold was evaluated using three Tail-flick, Hot-plate, and Formalin tests. Our results showed that Alzheimer's decreased the pain threshold in all three behavioral tests. Combined exercise with hawthorn consumption had the most statistically significant effect on Alzheimer's male rats' pain threshold in all three experiments. A combination of swimming endurance and resistance exercises with hawthorn consumption may modulate hyperalgesia in Alzheimer's rats. Future studies need to determine the effects of these factors on the treatment and/or management of painful conditions.
运动能提高健康人群的痛阈。然而，由于运动和山楂可能对持续性疼痛人群（包括阿尔茨海默病患者）有益，其对痛阈的调节作用尚不清楚。因此，我们通过三甲基氯化物诱导阿尔茨海默病后，对阿尔茨海默病雄性大鼠进行了为期 12 周的训练，包括抗阻训练、游泳耐力训练和综合训练。此外，还对大鼠进行了山楂提取物的口服给药。然后，使用三种尾部闪烁、热板和福尔马林测试来评估它们的痛阈。结果表明，阿尔茨海默病降低了所有三种行为测试中的痛阈。在所有三种实验中，山楂摄入与综合运动对阿尔茨海默病雄性大鼠的痛阈有最显著的统计学影响。游泳耐力和抗阻运动与山楂摄入的结合可能会调节阿尔茨海默病大鼠的痛觉过敏。未来的研究需要确定这些因素对治疗和/或管理疼痛状况的影响。
