Tong Min, Li Yuanyuan, Rong Kai, Sun Qi, Dai Jianghong, Huang Yifei
The Second Spine Department, Traditional Chinese Medicine Affiliated Hospital of Xinjiang Medical University, No. 116 Huanghe Road, Urumqi, 830000, China.
School of Public Health, Xinjiang Medical University, Urumqi, 830011, China.
J Orthop Surg Res. 2024 Jul 16;19(1):408. doi: 10.1186/s13018-024-04888-5.
Osteoporosis is a considerable public health challenge in Moyu County, Xinjiang. Here, we evaluated the influencing factors of osteoporosis in this region.
We recruited 7,761 participants and randomized them into normal and osteoporotic populations based on T-score. The effects of general conditions, body composition, calcium sources and exercise, respiratory exposure, and daily diet on osteoporosis were analyzed. Furthermore, a structural equation model was constructed to uncover the direct and indirect influencing factors of osteoporosis.
Among the participants, 1,803 (23.23%) had normal bone mass while 1,496 (19.28%) had osteoporosis. The univariate analysis showed significant differences in the general conditions, body composition, calcium sources and exercise, respiratory exposure, and daily diet. Stratification based on age (45 years) and body mass index (BMI) (18.5 kg/m) showed variations in the body composition between the two groups; however, the visceral fat differed significantly. Logistic regression analysis affirmed the association of visceral fat index as it was included in all equations, except for age and female menopause. The structural equation exhibited that the general conditions, body composition, and, calcium sources, and exercise were direct factors of osteoporosis, while respiratory exposure and daily diet were indirect factors. The standardized path coefficient was highest in general conditions, followed by body composition, and lastly, calcium sources and exercise.
Obesity, besides age and female menopause, is also an influencing factor of osteoporosis. The visceral fat index plays a vital role in osteoporosis. Our findings may provide experimental evidence for early prevention and treatment of osteoporosis.
骨质疏松症是新疆墨玉县面临的一项重大公共卫生挑战。在此，我们评估了该地区骨质疏松症的影响因素。
我们招募了7761名参与者，并根据T值将他们随机分为正常人群和骨质疏松人群。分析了一般状况、身体成分、钙源与运动、呼吸暴露及日常饮食对骨质疏松症的影响。此外，构建了结构方程模型以揭示骨质疏松症的直接和间接影响因素。
在参与者中，1803人（23.23%）骨量正常，1496人（19.28%）患有骨质疏松症。单因素分析显示，在一般状况、身体成分、钙源与运动、呼吸暴露及日常饮食方面存在显著差异。按年龄（45岁）和体重指数（BMI）（18.5kg/m²）分层显示，两组之间身体成分存在差异；然而，内脏脂肪差异显著。逻辑回归分析证实了内脏脂肪指数的关联性，因为除年龄和女性绝经外，它在所有方程中均有体现。结构方程表明，一般状况、身体成分、钙源与运动是骨质疏松症的直接因素，而呼吸暴露和日常饮食是间接因素。标准化路径系数在一般状况中最高，其次是身体成分，最后是钙源与运动。
除年龄和女性绝经外，肥胖也是骨质疏松症的一个影响因素。内脏脂肪指数在骨质疏松症中起着至关重要的作用。我们的研究结果可能为骨质疏松症的早期预防和治疗提供实验依据。
