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评估长链异麦芽低聚糖对糖尿病和高脂血症大鼠的治疗潜力。

Assessing the therapeutic potential of long-chain isomaltooligosaccharides in diabetic and hyperlipidemic rats.

作者信息

Reamtong Onrapak, Waeonukul Rattiya, Prangthip Pattaneeya

机构信息

Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Excellent Center of Enzyme Technology and Microbial Utilization, Pilot Plant Development and Training Institute (PDTI), King Mongkut's University of Technology Thonburi (KMUTT), Bangkok, 10150, Thailand.

出版信息

Diabetol Metab Syndr. 2024 Jul 16;16(1):165. doi: 10.1186/s13098-024-01374-0.

DOI:10.1186/s13098-024-01374-0
PMID:39014451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11253390/
Abstract

BACKGROUND

The global rise in diabetes prevalence necessitates effective treatments. Rats, mimicking physiological changes seen in Type 2 diabetes, serve as valuable models for studying metabolic disorders. Natural health supplements, especially prebiotics, are gaining interest for improving metabolic health. Isomaltooligosaccharides (IMOs), classified as functional oligosaccharides and prebiotics, have attracted attention due to their beneficial effects on gut microbiota balance and cholesterol reduction. However, commercial IMOs often contain undesirable sugars, leading to the development of long-chain IMOs with enhanced prebiotic properties.

METHODS

This study assessed the therapeutic potential of long-chain IMOs derived from Bacillus subtilis strain AP-1 compared to inulin, a widely recognized prebiotic, in addressing hyperglycemia and hyperlipidemia in rats.

RESULTS

IMOs treatment effectively reduced blood sugar and triglyceride levels similarly to inulin supplementation. Proteomic analysis revealed changes in hepatic protein profiles, with upregulated pathways including glutathione metabolism, oxidative phosphorylation, and pentose and glucuronate interconversion, while pathways related to fatty acid and amino acid biosynthesis exhibited downregulation. These results suggest promising therapeutic effects of IMOs treatment on diabetes and hyperlipidemia by influencing key metabolic pathways.

CONCLUSIONS

Our findings highlight the potential of long-chain IMOs as targeted interventions for metabolic disorders, warranting further investigation into their clinical applicability and mechanisms of action.

摘要

背景

全球糖尿病患病率的上升需要有效的治疗方法。大鼠可模拟2型糖尿病中出现的生理变化，是研究代谢紊乱的宝贵模型。天然健康补充剂，尤其是益生元，在改善代谢健康方面正受到越来越多的关注。异麦芽低聚糖（IMOs）被归类为功能性低聚糖和益生元，因其对肠道微生物群平衡和降低胆固醇的有益作用而受到关注。然而，商业IMOs通常含有不良糖类，因此人们开发了具有增强益生元特性的长链IMOs。

方法

本研究评估了与广泛认可的益生元菊粉相比，源自枯草芽孢杆菌AP-1菌株的长链IMOs在解决大鼠高血糖和高血脂问题方面的治疗潜力。

结果

IMOs治疗与补充菊粉类似，有效降低了血糖和甘油三酯水平。蛋白质组学分析揭示了肝脏蛋白质谱的变化，上调的途径包括谷胱甘肽代谢、氧化磷酸化以及戊糖和葡萄糖醛酸相互转化，而与脂肪酸和氨基酸生物合成相关的途径则表现出下调。这些结果表明IMOs治疗通过影响关键代谢途径对糖尿病和高血脂具有良好的治疗效果。

结论

我们的研究结果突出了长链IMOs作为代谢紊乱靶向干预措施的潜力，值得进一步研究其临床适用性和作用机制。

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Molecular Docking and Site-Directed Mutagenesis of GH49 Family Dextranase for the Preparation of High-Degree Polymerization Isomaltooligosaccharide.GH49 家族支链淀粉酶的分子对接和定点突变用于制备高聚合度异麦芽低聚糖。
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