Key Laboratory for Regenerative Medicine of the Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, 999077, China.
Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, 999077, China.
Adv Sci (Weinh). 2023 Jun;10(18):e2207418. doi: 10.1002/advs.202207418. Epub 2023 Apr 24.
Resolving inflammation and promoting intestinal tissue regeneration are critical for inflammatory bowel disease (IBD) treatment. Bioactive glass (BG) is a clinically approved bone graft material and has been shown to modulate inflammatory response, but it is unknown whether BG can be applied to treat IBD. Here, it is reported that BG attenuates pro-inflammatory response of lipopolysaccharide (LPS)-stimulated macrophages and hence reduces inflammatory damage to intestinal organoids in vitro. In addition, zein/sodium alginate-based core-shell microspheres (Zein/SA/BG) are developed for oral delivery of BG, which helps prevent premature dissolution of BG in the stomach. The results show that Zein/SA/BG protects BG from a gastric-simulated environment while dissolved in an intestinal-simulated environment. When administered to acute and chronic colitis mice model, Zein/SA/BG significantly reduces intestinal inflammation, promotes epithelial tissue regeneration, and partially restores microbiota homeostasis. These findings are the first to reveal the therapeutic efficacy of BG against IBD, which may provide a new therapeutic approach at low cost for effective IBD treatment.
解决炎症和促进肠道组织再生是治疗炎症性肠病（IBD）的关键。生物活性玻璃（BG）是一种临床认可的骨移植材料，已被证明可调节炎症反应，但尚不清楚 BG 是否可用于治疗 IBD。本文报道 BG 可减弱脂多糖（LPS）刺激的巨噬细胞的促炎反应，从而减少体外肠道类器官的炎症损伤。此外，还开发了基于玉米醇溶蛋白/海藻酸钠的核壳微球（Zein/SA/BG）用于 BG 的口服递送，有助于防止 BG 在胃中过早溶解。结果表明，Zein/SA/BG 在胃模拟环境中保护 BG 不被溶解，而在肠模拟环境中溶解。当将其施用于急性和慢性结肠炎小鼠模型时，Zein/SA/BG 可显著减轻肠道炎症，促进上皮组织再生，并部分恢复微生物组平衡。这些发现首次揭示了 BG 治疗 IBD 的疗效，这可能为有效治疗 IBD 提供一种低成本的新治疗方法。
