El-Nashar Heba A S, Eldahshan Omayma A, Nilofar Nilofar, Zengin Gokhan
Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.
Department of Biology, Science Faculty, Selcuk University, Konya, Turkey.
Nat Prod Res. 2024 Jul 17:1-5. doi: 10.1080/14786419.2024.2381030.
L. is a desert aromatic herb with a characteristic fragrance and taste belonging to the family Asteraceae. This study aimed to evaluate the chemical composition of essential oil isolated from L. using GC-MS analysis, along with an investigation of its antioxidant properties and inhibitory activity against key enzymes involved in the pathogenesis of Alzheimer's, diabetes mellitus, and skin pigmentation. GC-MS analysis of the oil revealed the identification of fourteen compounds (97.89%), predominated by piperitone (51.40%), followed by ethyl ()-cinnamate (20.44%), (+)-2-bornanone (5.63%), and ethyl-()-cinnamate (4.78%). The oil demonstrated remarkable antioxidant activities in the following order: ABTS (66.81 ± 1.49 mgTE/g)< CUPRAC (66.24 ± 0.53mgTE/g)<FRAP (58.68 ± 0.54 mgTE/g < PBD (17.81 ± 0.01 mmolTE/g (<DPPH) 8.55 ± 1.10mgTE/g(.The oil showed potent inhibitory effects against AChE and BChE at 2.14 ± 0.18 and 3.27 ± 0.04 mg GALAE/g, respectively. Further, it could inhibit tyrosinase and -amylase at 91.20 ± 7.29 mg KAE/g and 0.28 ± 0.01 mmol ACAE/g, respectively. Thus, oil may be utilized as adjuvant herbal therapy.
L.是一种属于菊科的具有独特香气和味道的沙漠芳香草本植物。本研究旨在通过气相色谱 - 质谱联用（GC - MS）分析评估从L.中分离出的精油的化学成分，并研究其抗氧化性能以及对参与阿尔茨海默病、糖尿病和皮肤色素沉着发病机制的关键酶的抑制活性。对该精油的GC - MS分析鉴定出了十四种化合物（占97.89%），其中胡椒酮占主导（51.40%），其次是（E） - 肉桂酸乙酯（20.44%）、（+） - 2 - 冰片酮（5.63%）和（Z） - 肉桂酸乙酯（4.78%）。该精油表现出显著的抗氧化活性，顺序如下：ABTS（66.81±1.49 mgTE/g）<CUPRAC（66.24±0.53mgTE/g）<FRAP（58.68±0.54 mgTE/g）<PBD（17.81±0.01 mmolTE/g）<DPPH（8.55±1.10mgTE/g）。该精油对乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）分别表现出强效抑制作用，浓度分别为2.14±0.18和3.27±0.04 mg GALAE/g。此外，它分别能以91.20±7.29 mg KAE/g和0.28±0.01 mmol ACAE/g的浓度抑制酪氨酸酶和α - 淀粉酶。因此，该精油可作为辅助草药疗法使用。
