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开发并验证一个及时且具有代表性的有限元人体脊柱模型,用于生物力学模拟。

Development and validation of a timely and representative finite element human spine model for biomechanical simulations.

机构信息

Musculoskeletal Biomechanics Research Laboratory, Department of Mechanical Engineering, McGill University, 817 Sherbrooke Street West, Macdonald Eng. Bldg. Office #153, Montreal, QC, H3A 0C3, Canada.

出版信息

Sci Rep. 2020 Dec 9;10(1):21519. doi: 10.1038/s41598-020-77469-1.

DOI:10.1038/s41598-020-77469-1
PMID:33298988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7725813/
Abstract

Numerous spine Finite Element (FE) models have been developed to assess spinal tolerances, spinal loadings and low back pain-related issues. However, justified simplifications, in terms of tissue decomposition and inclusion, for such a complex system may overlook crucial information. Thus, the purpose of this research was to develop and validate a comprehensive and representative spine FE model inclusive of an accurate representation of all major torso elements. A comprehensive model comprised of 273 tissues was developed via a novel FE meshing method to enhance computational feasibility. A comprehensive set of indirect validation tests were carried out to validate every aspect of the model. Under an increasing angular displacement of 24°-41°, the lumbar spine recorded an increasing moment from 5.5 to 9.3 Nm with an increase in IVD pressures from 0.41 to 0.66 MPa. Under forward flexion, vertical vertebral displacements simulated a 6% and 13% maximum discrepancy for intra-abdominal and intramuscular pressure results, all closely resembling previously documented in silico measured values. The developed state-of-the-art model includes most physiological tissues known to contribute to spinal loadings. Given the simulation's accuracy, confirmed by its validation tests, the developed model may serve as a reliable spinal assessment tool.

摘要

已经开发出许多脊柱有限元 (FE) 模型来评估脊柱耐受性、脊柱负荷和与下腰痛相关的问题。然而,对于这样一个复杂的系统,为了进行合理的简化,在组织分解和包含方面可能会忽略关键信息。因此,本研究的目的是开发和验证一种全面且具有代表性的脊柱 FE 模型,其中包括对所有主要躯干元素的准确表示。通过一种新颖的 FE 网格划分方法开发了一个由 273 个组织组成的综合模型,以提高计算可行性。进行了一整套综合的间接验证测试来验证模型的各个方面。在 24°-41°的逐渐增加的角位移下,腰椎记录了从 5.5 到 9.3 Nm 的不断增加的力矩,同时椎间盘压力从 0.41 增加到 0.66 MPa。在前屈时,模拟的垂直椎体位移对于腹内和肌肉内压力结果分别有 6%和 13%的最大差异,所有这些都与之前文献中记录的数值非常相似。所开发的最先进模型包括已知对脊柱负荷有贡献的大多数生理组织。鉴于其验证测试所确认的模拟准确性,所开发的模型可以作为一种可靠的脊柱评估工具。

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