Hu Siwang, Han Xuebing, Liu Gang, Wang Shuangshuang
The Orthopedic Center, Wenling First People's Hospital (The Affiliated Wenling Hospital of Wenzhou Medical University), Wenling, China.
Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China.
Front Endocrinol (Lausanne). 2024 Jul 2;15:1415722. doi: 10.3389/fendo.2024.1415722. eCollection 2024.
Osteosarcoma is a common malignancy that often occurs in children, teenagers and young adults. Although the treatment strategy has improved, the results are still poor for most patients with metastatic or recurrent osteosarcomas. Therefore, it is necessary to identify new and effective prognostic biomarkers and therapeutic targets for diseases. Human genomes contain lncRNAs, transcripts with limited or insufficient capacity to encode proteins. They have been implicated in tumorigenesis, particularly regarding the onset, advancement, resistance to treatment, recurrence and remote dissemination of malignancies. Aberrant lncRNA expression in osteosarcomas has been reported by numerous researchers; lncRNAs have the potential to exhibit either oncogenic or tumor-suppressing behaviors and thus, to govern the advancement of this skeletal cancer. They are suspected to influence osteosarcoma cell growth, replication, invasion, migration, remote dissemination and programmed cell death. Additionally, they have been recognized as clinical markers, and may participate in the development of multidrug resistance. Therefore, the study of lncRNAs in the growth, metastasis, treatment and prognosis of osteosarcoma is very important for the active prevention and treatment of osteosarcoma. Consequently, this work reviews the functions of lncRNAs.
骨肉瘤是一种常见的恶性肿瘤，常发生于儿童、青少年和年轻成年人。尽管治疗策略有所改进，但对于大多数转移性或复发性骨肉瘤患者来说，治疗效果仍然不佳。因此，有必要为该疾病确定新的有效预后生物标志物和治疗靶点。人类基因组包含长链非编码RNA（lncRNA），即编码蛋白质能力有限或不足的转录本。它们与肿瘤发生有关，特别是在恶性肿瘤的发生、进展、治疗耐药性、复发和远处转移方面。许多研究人员报道了骨肉瘤中异常的lncRNA表达；lncRNA有可能表现出致癌或抑癌行为，从而控制这种骨骼癌症的进展。它们被怀疑会影响骨肉瘤细胞的生长、复制、侵袭、迁移、远处转移和程序性细胞死亡。此外，它们已被确认为临床标志物，并可能参与多药耐药性的产生。因此，研究lncRNA在骨肉瘤生长、转移、治疗和预后中的作用对于骨肉瘤的积极防治非常重要。因此，本文综述了lncRNA的功能。
