FER1L4：一种在肿瘤发生和发展中具有多种作用的长非编码 RNA。
FER1L4: A Long Non-coding RNA with Multiple Roles in the Occurrence and Development of Tumors.
机构信息
Medical College, China Three Gorges University, Yichang 443002, China.
Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, China.
出版信息
Curr Pharm Des. 2022;28(16):1334-1341. doi: 10.2174/1381612828666220324141016.
BACKGROUND
FER-1 family member 4 (FER1L4), a 6.7 kb lncRNA located at 20q11.22, plays an important biological function in a variety of tumor diseases. The purpose of this review is to clarify the pathophysiological mechanism and potential biological function of FER1L4 in different tumors.
METHODS
By searching the relevant literature in PubMed, the specific pathophysiological mechanism of FER1L4 in different tumors was summarized.
RESULTS
LncRNA FER1L4 is one of the key factors in tumorigenesis and is abnormally down-regulated in many tumors, including osteosarcoma, lung cancer, laryngeal squamous cell carcinoma, laryngeal cancer, colorectal cancer, ovarian cancer, prostate cancer, esophageal cancer, gastric cancer, endometrial cancer, osteoarthritis, rheumatoid arthritis, and so on. However, FER1L4 is downregulated in breast cancer, glioma, oral squamous cell carcinoma, renal clear cell carcinoma, and periodontitis, and plays a protective role in orthodontic teeth. In addition, as a tumor suppressor gene or oncogene, FER1L4 affects tumor proliferation, invasion, migration, and apoptosis.
CONCLUSION
LncRNA FER1L4 has a good application prospect in the treatment and diagnosis of various tumors.
背景
FER-1 家族成员 4（FER1L4）是一种位于 20q11.22 的 6.7kb 的长链非编码 RNA，在多种肿瘤疾病中发挥着重要的生物学功能。本综述旨在阐明 FER1L4 在不同肿瘤中的病理生理机制和潜在生物学功能。
方法
通过在 PubMed 中搜索相关文献，总结了 FER1L4 在不同肿瘤中的具体病理生理机制。
结果
lncRNA FER1L4 是肿瘤发生的关键因素之一，在许多肿瘤中异常下调，包括骨肉瘤、肺癌、喉鳞状细胞癌、喉癌、结直肠癌、卵巢癌、前列腺癌、食管癌、胃癌、子宫内膜癌、骨关节炎、类风湿关节炎等。然而，在乳腺癌、神经胶质瘤、口腔鳞状细胞癌、肾透明细胞癌和牙周炎中，FER1L4 下调，并在正畸牙齿中发挥保护作用。此外，作为肿瘤抑制基因或癌基因，FER1L4 影响肿瘤的增殖、侵袭、迁移和凋亡。
结论
lncRNA FER1L4 在各种肿瘤的治疗和诊断中有很好的应用前景。
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