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LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy.

作者信息

Huang Xin, Zhang Weiyue, Pu Feifei, Zhang Zhicai

机构信息

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

出版信息

Genes Dis. 2021 Nov 24;10(2):531-541. doi: 10.1016/j.gendis.2021.11.004. eCollection 2023 Mar.

DOI:10.1016/j.gendis.2021.11.004
PMID:37223512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10201553/
Abstract

This study aimed to investigate the role of long non-coding RNA maternally expressed gene 3 (lncRNA MEG3) in chemosensitivity of osteosarcoma (OS), and to reveal the possible underlying mechanisms. In this study, we found that the expression of lncRNA MEG3 was significantly lower in OS tissues and cell lines. Furthermore, lncRNA MEG3 overexpression enhanced chemosensitivity of OS by inhibiting cell proliferation, migration, autophagy, and promoting antitumor immunity. LncRNA MEG3 functioned as miR-21-5 sponge to regulate p53 expression in OS. Mechanically, lncRNA MEG3 promoted OS chemosensitivity by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy. Collectively, this study provided the evidence that lncRNA MEG3 might be a promising therapeutic target for OS chemoresistance.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/6ce131ac7e12/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/2ffa1963b06a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/38348bd18c62/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/152a6261a24e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/fe3ae29f3f31/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/74de6579f857/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/6ce131ac7e12/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/2ffa1963b06a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/38348bd18c62/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/152a6261a24e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/fe3ae29f3f31/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/74de6579f857/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee61/10201553/6ce131ac7e12/gr6.jpg

相似文献

[1]
LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy.

Genes Dis. 2021-11-24

[2]
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[3]
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[6]
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[10]
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引用本文的文献

[1]
LncRNA OLMALINC promotes osteosarcoma progression through USP1-mediated autophagy suppression.

Hum Cell. 2025-4-18

[2]
Nrf2: A key regulator in chemoradiotherapy resistance of osteosarcoma.

Genes Dis. 2024-5-22

[3]
Unraveling the role of long non-coding RNAs in therapeutic resistance in acute myeloid leukemia: New prospects & challenges.

Noncoding RNA Res. 2024-5-20

[4]
LncRNAs as potential prognosis/diagnosis markers and factors driving drug resistance of osteosarcoma, a review.

Front Endocrinol (Lausanne). 2024-7-2

[5]
A possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet's disease.

Immunogenetics. 2024-8

[6]
Emerging roles of long non-coding RNAs in osteosarcoma.

Front Mol Biosci. 2024-3-7

[7]
Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway.

Genes Dis. 2022-8-6

本文引用的文献

[1]
Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1.

Nat Commun. 2021-8-16

[2]
Drug Resistance in Osteosarcoma: Emerging Biomarkers, Therapeutic Targets and Treatment Strategies.

Cancers (Basel). 2021-6-9

[3]
Functional roles of lncRNAs in the pathogenesis and progression of cancer.

Genes Dis. 2020-4-21

[4]
Immune checkpoint: The novel target for antitumor therapy.

Genes Dis. 2019-12-20

[5]
First-Line Immune Checkpoint Inhibition for Advanced Non-Small-Cell Lung Cancer: State of the Art and Future Directions.

Drugs. 2020-11

[6]
Targeting Molecular Mechanisms Underlying Treatment Efficacy and Resistance in Osteosarcoma: A Review of Current and Future Strategies.

Int J Mol Sci. 2020-9-19

[7]
Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies.

Genes Dis. 2019-7-3

[8]
LncRNA MEG3 inhibits proliferation and promotes apoptosis of osteosarcoma cells through regulating Notch signaling pathway.

Eur Rev Med Pharmacol Sci. 2020-1

[9]
Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma.

Int J Oncol. 2019-10-18

[10]
Emerging roles of lncRNAs in the post-transcriptional regulation in cancer.

Genes Dis. 2019-2-11

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