Murillo Moreno Mauricio Andrés, López Gutiérrez Laura Valentina, Vinck Eric Edward, Roncancio Villamil Gustavo, Gallego Muñoz Catalina, Saldarriaga Giraldo Clara Inés
Departamento de Medicina Interna, Universidad CES, Medellín, Colombia. Universidad CES Departamento de Medicina Interna Universidad CES Medellín Colombia.
Departamento de Cardiología, Clínica Cardio VID, Medellín, Colombia. Departamento de Cardiología Clínica Cardio VID Medellín Colombia.
Arch Peru Cardiol Cir Cardiovasc. 2024 Jun 24;5(2):e375. doi: 10.47487/apcyccv.v5i2.375. eCollection 2024 Apr-Jun.
Tuberculosis is an increasing disease that affects about one-third of the global population. In line with the rise of tuberculosis, cardiovascular disease has shown a similar trend, with ischemic coronary heart disease becoming the leading cause of death worldwide. Based on the literature, a relationship can be drawn between tuberculosis and ischemic coronary heart disease through their shared multiple risk factors and a possible pathophysiological substrate linking them. The presentation of these two conditions reported so far is varied: it has been found as the onset of acute coronary syndrome in patients with active tuberculosis, the progressive development of coronary atherosclerosis in patients with latent tuberculosis, among others. Given this possible link and the progressive increase in their incidence rates, we can assert that we are facing an unnoticed syndemic, with their concurrent management posing a challenge due to significant pharmacological interactions. The purpose of this review is to clarify this possible link, propose an approach for diagnosis, and provide a treatment algorithm for the entire spectrum of coronary disease coexisting with tuberculosis according to the current available literature.
结核病是一种发病率不断上升的疾病，影响着全球约三分之一的人口。随着结核病发病率的上升，心血管疾病也呈现出类似趋势，缺血性冠心病已成为全球主要死因。根据文献，结核病和缺血性冠心病之间可通过它们共有的多种风险因素以及可能将二者联系起来的病理生理基础建立关联。迄今为止报道的这两种疾病的表现各不相同：在活动性结核病患者中表现为急性冠状动脉综合征的发作，在潜伏性结核病患者中表现为冠状动脉粥样硬化的渐进发展等等。鉴于这种可能的关联以及它们发病率的不断上升，我们可以断言我们正面临一种未被注意到的综合征，由于显著的药物相互作用，对它们的同时治疗构成了挑战。本综述的目的是阐明这种可能的关联，提出一种诊断方法，并根据当前可得文献为与结核病共存的整个冠状动脉疾病谱提供一种治疗算法。
