由内而外和由外而内地构建天然生物复杂性。
Engineering Native Biological Complexity from the Inside-out and Outside-in.
作者信息
DeForest Cole A, Kirkpatrick Bruce E, Anseth Kristi S
机构信息
Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
出版信息
Nat Chem Eng. 2024 Jan;1(1):2-5. doi: 10.1038/s44286-023-00013-1. Epub 2024 Jan 11.
Abstract
Focusing on engineering control over cell function and fate, this article examines the critical balance of 'outside-in' and 'inside-ouť signaling in tissue development and regeneration. It highlights emerging strategies to manipulate these interactions, including biomaterial design and synthetic biology to influence this delicate equilibrium and fine tune cellular responses.
摘要
本文聚焦于对细胞功能和命运的工程控制，探讨了组织发育和再生过程中“由外向内”和“由内向外”信号传导的关键平衡。文中强调了操纵这些相互作用的新兴策略，包括生物材料设计和合成生物学，以影响这种微妙的平衡并精确调节细胞反应。
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