恒河猴（Rh）抗原的分布模式
The Distribution Patterns of Rhesus (Rh) Antigens.
作者信息
Raghuwanshi Babita, Ahuja Kanchan, Sharma Garima, Sharma Kalpana, Singh Meghna, Yadav Aarti, Kumar Subhash, Sharma Pankaj K, Chander Harish, Dubey Devesh
机构信息
Transfusion Medicine, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Blood Reagent Laboratory, National Institute of Biologicals, Noida, IND.
出版信息
Cureus. 2024 Jun 16;16(6):e62476. doi: 10.7759/cureus.62476. eCollection 2024 Jun.
INTRODUCTION
The determination of one's blood group is dictated by the inheritance-based diversity in the presence or absence of RBC antigens on the surface. Extended Rhesus (Rh) antigens are the most clinically relevant antigens of blood group systems after the ABO blood group system in transfusion medicine. The aim of this study was to serologically assess the prevalence of extended Rh antigens across diverse blood group systems.
METHODS
A total of 2043 samples were tested for the ABO blood group and Rh typing with monoclonal antisera. The Rh phenotyping (C, c, E, e ) was performed on all the samples.
RESULTS
The most frequently observed ABO blood group was O (36.5%), while AB (13.6%) was identified as the least prevalent. Positive Rh D antigen was found in 91.6% of tested samples, while 8.4% were Rh D-negative. The most frequently encountered antigen was e, followed by D, while the least prevalent was E.
DISCUSSION
Establishing a Rh phenotype repository for blood donors and conducting Rh phenotype assessments as part of pretransfusion testing before initiating the initial blood transfusion for each patient could significantly lower the patients' incidence of alloimmunization.
引言
一个人的血型由红细胞表面基于遗传的抗原存在与否的多样性决定。在输血医学中，扩展的恒河猴（Rh）抗原是继ABO血型系统之后血型系统中最具临床相关性的抗原。本研究的目的是通过血清学方法评估不同血型系统中扩展Rh抗原的流行情况。
方法
用单克隆抗血清对总共2043份样本进行ABO血型和Rh分型检测。对所有样本进行Rh表型分析（C、c、E、e）。
结果
最常观察到的ABO血型是O型（36.5%），而AB型（13.6%）被确定为最不常见。在91.6%的检测样本中发现Rh D抗原呈阳性，而8.4%为Rh D阴性。最常遇到的抗原是e，其次是D，最不常见的是E。
讨论
为献血者建立Rh表型库，并在为每位患者首次输血前进行输血前检测时进行Rh表型评估，可显著降低患者同种免疫的发生率。
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