Council of Periodontology and Dental Public Health, Sudan Medical Specialization Board, Khartoum, Sudan.
Associate Professor of Restorative Dentistry, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan.
Complement Ther Clin Pract. 2021 May;43:101383. doi: 10.1016/j.ctcp.2021.101383. Epub 2021 Apr 2.
Pomegranate is one of the most universally studied medicinal plants for its ethnomedical history, with several studies presenting the positive outcome of its use or its extracts in managing inflammation. The objective of the present trial was to investigate the efficiency of the traditionally used 5% of pomegranate peel extract in treating gingival inflammation. Herein, 34 chronic gingivitis patients were randomized in a 1:1 ratio for four weeks in a controlled, double-blind clinical trial to evaluate the effect of the adjunctive use of a pulsating jet irrigator containing 5% pomegranate peel extract solution to nonsurgical periodontal therapy against a placebo in managing these patients' condition. No adverse reactions had been reported, and within the limits of this study, it may be concluded that pomegranate peel extract can serve as a promising alternative in managing chronic gingivitis. This trial is registered on the German clinical trials register (DRKS-ID: DRKS00010602).
石榴是一种被广泛研究的药用植物，因其在民族医学中的历史而受到关注，有多项研究表明其使用或提取物在治疗炎症方面具有积极效果。本试验旨在研究传统使用的 5%石榴皮提取物在治疗牙龈炎症方面的功效。在此，34 名慢性牙龈炎患者被随机分为两组，每组 17 人，进行为期四周的对照、双盲临床试验，以评估在非手术牙周治疗中辅助使用含有 5%石榴皮提取物溶液的脉动射流冲洗器与安慰剂相比对患者病情的影响。未报告不良反应，在本研究的范围内，可以得出结论，石榴皮提取物可以作为治疗慢性牙龈炎的一种有前途的替代方法。该试验在德国临床试验注册中心（DRKS-ID：DRKS00010602）注册。
