Terpstra W J, Korver H, van Leeuwen J, Klatser P R, Kolk A H
Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Jul;259(4):498-506. doi: 10.1016/s0176-6724(85)80082-1.
Using the hybridoma technique we produced monoclonal antibodies to serovars of Leptospira interrogans. We focussed on serovar hardjo which is an important pathogen for humans and animals, and on other serovars of the Sejroe group. With combinations of monoclonals, characteristic patterns of agglutination were observed according to the specific pattern of antigenic determinants of that serovar. A set of 13 monoclonal antibodies was composed which allowed the classification of almost all serovars of the Sejroe group.
我们使用杂交瘤技术制备了针对问号钩端螺旋体血清型的单克隆抗体。我们重点研究了对人和动物而言均为重要病原体的哈德乔血清型，以及 sejroe 群的其他血清型。通过单克隆抗体的组合，根据该血清型抗原决定簇的特定模式观察到了特征性的凝集模式。我们构建了一组 13 种单克隆抗体，可用于对 sejroe 群的几乎所有血清型进行分类。
