抗抑郁治疗：前景中的益处与风险
Antidepressant therapy: benefits and risks in perspective.
作者信息
Burrows G D, Norman T R, Dennerstein L, Davies B M
出版信息
Acta Psychiatr Scand Suppl. 1985;320:43-7. doi: 10.1111/j.1600-0447.1985.tb08074.x.
The introduction of second generation antidepressants, such as mianserin and nomifensine, was prompted by the desire to produce drugs which were safer, had fewer side-effects and were faster acting than the tricyclics. A brief review of the data on mianserin and nomifensine is presented in relation to these aims. Some advantages for the new drugs can be claimed and the risks of severe adverse effects relating to blood dyscrasias in the case of mianserin, and fever in the case of nomifensine, appear outweighed by the therapeutic gains.
第二代抗抑郁药，如米安色林和诺米芬辛的推出，是出于研发比三环类药物更安全、副作用更少且起效更快的药物的需求。本文围绕这些目标，简要回顾了米安色林和诺米芬辛的数据。新药物有一些优势，米安色林引发血液系统疾病以及诺米芬辛引发发热的严重不良反应风险，似乎被治疗效果所抵消。
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