Department of Hematology, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi, People's Republic of China.
Hematology. 2024 Dec;29(1):2379178. doi: 10.1080/16078454.2024.2379178. Epub 2024 Jul 17.
Observational studies have found a link between lipid metabolism disorders and aplastic anemia (AA). However, due to confounding variables and reverse causation, it is difficult to conclude such a causal link. The precise mechanism and potential implications of lipid metabolism disorder in AA remain unclear, necessitating further studies in this area.
This study aimed to examine the causal relationship between 38 different subtypes of triacylglycerols and AA using two-sample Mendelian randomization (MR). Additionally, two-step MR analyses were conducted to investigate the mediating effects of vitamin A to oleoyl-linoleoyl-glycerol (18:1-18:2) ratio.
MR analysis showed that triacylglycerol (53:3) levels were positively associated with the risk of AA [inverse variance weighting (IVW): odds ratio (OR) = 1.131,95% confidence interval (CI):1.029-1.243, = 0.011; Bayesian weighted MR (BWMR): OR = 1.137,95% CI:1.031-1.254, = 0.010]. Triacylglycerol (53:3) level showed no inverse causality with AA (IVW:= 0.834; BWMR:= 0.349). Mediation analyses showed that increasing the vitamin A to oleoyl-linoleoyl-glycerol (18:1-18:2) ratio can decrease the risk of AA.
This study revealed the association between vitamin A to oleoyl-linoleoyl-glycerol (18:1-18:2) ratio, triacylglycerol (53:3) levels and AA, and indicated that lowering triacylglycerol (53:3) levels can reduce the risk of AA.
观察性研究发现脂质代谢紊乱与再生障碍性贫血（AA）之间存在关联。然而，由于混杂变量和反向因果关系，很难得出这样的因果关系结论。脂质代谢紊乱与 AA 之间的确切机制和潜在影响尚不清楚，需要在这一领域进行进一步研究。
本研究旨在使用两样本 Mendelian 随机化（MR）检查 38 种不同三酰甘油亚型与 AA 之间的因果关系。此外，还进行了两步 MR 分析，以研究维生素 A 对油酰亚油酰甘油（18:1-18:2）比值的中介作用。
MR 分析表明，三酰甘油（53:3）水平与 AA 的风险呈正相关[逆方差加权（IVW）：比值比（OR）=1.131，95%置信区间（CI）：1.029-1.243，=0.011；贝叶斯加权 MR（BWMR）：OR=1.137，95%CI：1.031-1.254，=0.010]。三酰甘油（53:3）水平与 AA 之间没有反向因果关系（IVW：=0.834；BWMR：=0.349）。中介分析表明，增加维生素 A 对油酰亚油酰甘油（18:1-18:2）比值可以降低 AA 的风险。
本研究揭示了维生素 A 对油酰亚油酰甘油（18:1-18:2）比值、三酰甘油（53:3）水平与 AA 之间的关联，并表明降低三酰甘油（53:3）水平可以降低 AA 的风险。
