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本文引用的文献

1
Plasma eicosapentaenoic acid, a biomarker of fish consumption, is associated with perfluoroalkyl carboxylic acid exposure in residents of Kyoto, Japan: a cross-sectional study.血浆二十碳五烯酸，一种鱼类消费的生物标志物，与日本京都居民的全氟羧酸暴露有关：一项横断面研究。
Environ Health Prev Med. 2023;28:38. doi: 10.1265/ehpm.22-00302.
2
Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam.饮用水受消防泡沫污染停止暴露后短链和长链全氟烷基酸的血清半衰期。
Environ Health Perspect. 2020 Jul;128(7):77004. doi: 10.1289/EHP6785. Epub 2020 Jul 10.
3
Levels and profiles of long-chain perfluoroalkyl carboxylic acids in Pacific cod from 14 sites in the North Pacific Ocean.北太平洋 14 个站位的太平洋鳕鱼中长链全氟羧酸的水平和分布。
Environ Pollut. 2019 Apr;247:312-318. doi: 10.1016/j.envpol.2019.01.006. Epub 2019 Jan 4.
4
Contribution of diet and other factors to the levels of selected polyfluorinated compounds: data from NHANES 2003-2008.饮食和其他因素对选定多氟化合物水平的贡献：来自 NHANES 2003-2008 的数据。
Int J Hyg Environ Health. 2014 Jan;217(1):52-61. doi: 10.1016/j.ijheh.2013.03.008. Epub 2013 Mar 27.
5
Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population.日本人的海鲜消费、血清肝酶以及全氟辛烷磺酸和全氟辛酸的血液水平。
J Occup Health. 2013;55(3):184-94. doi: 10.1539/joh.12-0264-oa. Epub 2013 Apr 9.
6
Diet and particularly seafood are major sources of perfluorinated compounds in humans.饮食，尤其是海鲜，是人体内全氟化合物的主要来源。
Environ Int. 2010 Oct;36(7):772-8. doi: 10.1016/j.envint.2010.05.016. Epub 2010 Jul 1.

血浆中全氟辛烷磺酸的线性异构体而非支链异构体与二十碳五烯酸（一种海鲜消费生物标志物）相关。

Linear isomer but not branched isomers of perfluorooctane sulfonate in plasma is associated with eicosapentaenoic acid, a seafood consumption biomarker.

作者信息

Lyu Zhaoqing, Harada Kouji H, Sassa Mariko Harada, Fujii Yukiko

机构信息

Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine.

Department of Pharmaceutical Sciences, Daiichi University of Pharmacy.

出版信息

Environ Health Prev Med. 2024;29:35. doi: 10.1265/ehpm.24-00140.

DOI:10.1265/ehpm.24-00140
PMID:39019616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11273034/
Abstract

BACKGROUND

Per- and polyfluoroalkyl substances (PFAS) are global contaminants. Seafood consumption is a possible PFAS exposure route to humans while the isomer specific analysis has not been conducted.

METHODS

Perfluorooctane sulfonate (PFOS), perfluoroheptane sulfonate (PFHpS) and perfluorohexane sulfonate (PFHxS) were investigated in residents of Kyoto, Japan (n = 51). The relationship between plasma PFAS and seafood consumption biomarker, the ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA) was examined by multiple regression analysis.

RESULTS

Linear PFOS concentrations showed a significant positive correlation with the EPA/AA ratio in plasma samples (β = 6.80, p = 0.0014). Linear PFHpS was marginally associated with EPA/AA ratio (β = 0.178, p = 0.0874). Branched PFOS isomers and PFHxS had no associations with EPA/AA ratios.

CONCLUSION

Seafood intake may be a significant exposure pathway for PFAS, such as PFOS but the isomers differ.

摘要

背景

全氟和多氟烷基物质（PFAS）是全球污染物。食用海鲜是人类接触PFAS的一种可能途径，而尚未进行异构体特异性分析。

方法

对日本京都的居民（n = 51）进行了全氟辛烷磺酸（PFOS）、全氟庚烷磺酸（PFHpS）和全氟己烷磺酸（PFHxS）的研究。通过多元回归分析研究血浆PFAS与海鲜消费生物标志物二十碳五烯酸与花生四烯酸的比率（EPA/AA）之间的关系。

结果

血浆样本中线性PFOS浓度与EPA/AA比率呈显著正相关（β = 6.80，p = 0.0014）。线性PFHpS与EPA/AA比率存在微弱关联（β = 0.178，p = 0.0874）。支链PFOS异构体和PFHxS与EPA/AA比率无关联。

结论

摄入海鲜可能是PFAS（如PFOS）的重要暴露途径，但异构体有所不同。