Xu Jingxin, Wu Mingjun, Yang Jie, Zhao Dezhang, He Dan, Liu Yingju, Yan Xiong, Liu Yuying, Pu Daojun, Tan Qunyou, Zhang Ling, Zhang Jingqing
Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing, China.
Institute of Life Sciences, Chongqing Medical University, Chongqing, China.
Nat Nanotechnol. 2024 Oct;19(10):1544-1557. doi: 10.1038/s41565-024-01715-0. Epub 2024 Jul 17.
Gouty arthritis is a chronic and progressive disease characterized by high urate levels in the joints and by an inflammatory immune microenvironment. Clinical data indicate that urate reduction therapy or anti-inflammatory therapy alone often fails to deliver satisfactory outcomes. Here we have developed a smart biomimetic nanosystem featuring a 'shell' composed of a fusion membrane derived from M2 macrophages and exosomes, which encapsulates liposomes loaded with a combination of uricase, platinum-in-hyaluronan/polydopamine nanozyme and resveratrol. The nanosystem targets inflamed joints and promotes the accumulation of anti-inflammatory macrophages locally, while the uricase and the nanozyme reduce the levels of urate within the joints. Additionally, site-directed near-infrared irradiation provides localized mild thermotherapy through the action of platinum and polydopamine, initiating heat-induced tissue repair. Combined use of these components synergistically enhances overall outcomes, resulting in faster recovery of the damaged joint tissue.
痛风性关节炎是一种慢性进行性疾病，其特征是关节中尿酸水平升高以及存在炎症性免疫微环境。临床数据表明，单独的尿酸降低疗法或抗炎疗法往往无法取得令人满意的效果。在此，我们开发了一种智能仿生纳米系统，其“外壳”由源自M2巨噬细胞和外泌体的融合膜组成，该外壳包裹着负载有尿酸酶、透明质酸/聚多巴胺铂纳米酶和白藜芦醇组合的脂质体。该纳米系统靶向炎症关节并促进抗炎巨噬细胞在局部积累，同时尿酸酶和纳米酶降低关节内的尿酸水平。此外，定点近红外照射通过铂和聚多巴胺的作用提供局部温和热疗，启动热诱导的组织修复。这些成分的联合使用协同增强了整体效果，导致受损关节组织更快恢复。
