P Rihana Begum, Prajapati Bhupendra G, Rajeshkumar R, Balasubramaniam V, Ponnusankar Sivasankaran
Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty - 643 001, The Nilgiris, Tamil Nadu, India.
Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, 384012, India.
Curr Med Chem. 2024 Jul 15. doi: 10.2174/0109298673314366240712105637.
To overcome the limits of traditional antibiotic medications, novel approaches are needed to combat the growing global epidemic of Multidrug-resistant (MDR) infections. As drug-resistant bacteria develop, the importance of innovative antimicrobial methods is underscored by antibiotic abuse and misuse. The global threat of MDR microorganisms is increasing, which calls for a coordinated global response. Lipid Nanoparticles (LNPs) possess several characteristics that make them attractive choices for managing multidrug resistant (MDR) infections, as well as potential delivery systems for antimicrobial agents. Thus, LNPs improve drug solubility, stability, and targeted delivery, thereby mitigating the drawbacks of conventional antibiotic therapy. Several characteristics of LNPs, which stop MDR bacteria from developing resistance mechanisms, serve as guidelines for precision medicine. It presents a powerful approach for combating the growing concern of MDR bacteria by increasing Anti-Microbial Peptides (AMPs) bioavailability and targeting distribution to bacterial cells. LNPs have the potential to redefine antibacterial treatments for MDR illnesses in the context of this study. Further, it discusses LNP use in larger applications, such as fighting Anti-Microbial Resistance (AMR) and MDR. A complete understanding of the unique features, many uses, and importance of collaborative efforts to overcome the global challenge of antibiotic resistance are also conveyed in the study.
为克服传统抗生素药物的局限性，需要新的方法来应对全球日益严重的多重耐药（MDR）感染流行。随着耐药细菌的出现，抗生素滥用和误用凸显了创新抗菌方法的重要性。多重耐药微生物的全球威胁不断增加，这需要全球做出协调一致的应对。脂质纳米颗粒（LNPs）具有多种特性，使其成为治疗多重耐药（MDR）感染的有吸引力的选择，也是抗菌剂的潜在递送系统。因此，LNPs提高了药物的溶解度、稳定性和靶向递送能力，从而减轻了传统抗生素治疗的缺点。LNPs的几个特性可阻止多重耐药细菌产生耐药机制，为精准医学提供了指导。通过提高抗菌肽（AMPs）的生物利用度并将其靶向分布到细菌细胞，它为应对日益严重的多重耐药细菌问题提供了一种强有力的方法。在本研究中，LNPs有潜力重新定义多重耐药疾病的抗菌治疗方法。此外，它还讨论了LNPs在更大规模应用中的使用，如对抗抗菌耐药性（AMR）和多重耐药性。该研究还全面阐述了脂质纳米颗粒的独特特性、多种用途以及为克服抗生素耐药性这一全球挑战而开展合作的重要性。
