Department of Biosciences (UIBT), Chandigarh University, Punjab, 140413, India.
Arch Microbiol. 2024 May 28;206(6):280. doi: 10.1007/s00203-024-03998-2.
Antimicrobial resistance poses a significant global health threat, necessitating innovative approaches for combatting it. This review explores various mechanisms of antimicrobial resistance observed in various strains of bacteria. We examine various strategies, including antimicrobial peptides (AMPs), novel antimicrobial materials, drug delivery systems, vaccines, antibody therapies, and non-traditional antibiotic treatments. Through a comprehensive literature review, the efficacy and challenges of these strategies are evaluated. Findings reveal the potential of AMPs in combating resistance due to their unique mechanisms and lower propensity for resistance development. Additionally, novel drug delivery systems, such as nanoparticles, show promise in enhancing antibiotic efficacy and overcoming resistance mechanisms. Vaccines and antibody therapies offer preventive measures, although challenges exist in their development. Non-traditional antibiotic treatments, including CRISPR-Cas systems, present alternative approaches to combat resistance. Overall, this review underscores the importance of multifaceted strategies and coordinated global efforts to address antimicrobial resistance effectively.
抗菌药物耐药性对全球健康构成重大威胁，需要创新方法加以应对。本综述探讨了各种细菌菌株中观察到的抗菌药物耐药性机制。我们研究了各种策略，包括抗菌肽 (AMPs)、新型抗菌材料、药物输送系统、疫苗、抗体疗法和非传统抗生素治疗。通过全面的文献回顾，评估了这些策略的疗效和挑战。研究结果表明，由于 AMPs 具有独特的作用机制和较低的耐药性发展倾向，因此它们在对抗耐药性方面具有潜力。此外，新型药物输送系统，如纳米颗粒，在增强抗生素疗效和克服耐药机制方面显示出前景。疫苗和抗体疗法提供了预防措施，但在开发方面存在挑战。CRISPR-Cas 系统等非传统抗生素治疗方法提供了对抗耐药性的替代方法。总的来说，本综述强调了采取多方面策略和协调全球努力以有效应对抗菌药物耐药性的重要性。
