Feng Tianxing, Zheng Jiali, Wang Xiaoxiao, Wang Yilei, Shen Ping, Zhu Beili, Zhao Huiyan, Zhao Li, Xu Yaqing
Department of Medical Affairs, Shanghai Clinical Research and Trial Center, Shanghai 201203, China.
Department of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
J Endocr Soc. 2024 Jul 3;8(8):bvae128. doi: 10.1210/jendso/bvae128. eCollection 2024 Jul 1.
To estimate decadal trends in the prevalence of metabolic syndrome (MetS) in economically developed regions in China and its association with city economic levels.
Using a comprehensive Chinese healthcare database, repeated cross-sectional studies were conducted on adults who had annual health check-ups from 2012 to 2021 in 4 economically developed cities. MetS was defined by the criteria of the Chinese Diabetes Society in 2013. The crude prevalence of MetS adjusted for sex and age was reported. The association between prevalence, calendar year, and city gross domestic product (GDP) per capita was analyzed by regression model.
158 274 participants aged 18 years and older were included. The unadjusted prevalence of MetS increased from 15.5% (95% CI: 14.2%-16.8%) to 20.0% (95% CI: 19.5%-20.5%) from 2012 to 2021. The adjusted overall prevalence has increased steadily from 12.8% to 20.8% after controlling age and sex ( < .001). Male and older age groups had a higher MetS prevalence. In the regression model of the association between the MetS prevalence, calendar year, and city GDP per capita, calendar year had a positive association with the prevalence ( < .001, 95% CI: 0.648-1.954) and city GDP per capita had a negative association ( = .030, 95% CI: -0.136 to -0.007).
The MetS prevalence increased steadily in the economically developed regions in China among the health check-up population during 2012-2021. The MetS prevalence is shown to be negatively associated with GDP per capita in the study population.
评估中国经济发达地区代谢综合征（MetS）患病率的十年趋势及其与城市经济水平的关联。
利用一个综合性的中国医疗数据库，对2012年至2021年在4个经济发达城市进行年度健康检查的成年人开展重复横断面研究。MetS依据2013年中国糖尿病学会的标准进行定义。报告了经性别和年龄调整后的MetS粗患病率。通过回归模型分析患病率、历年以及城市人均国内生产总值（GDP）之间的关联。
纳入了158274名18岁及以上的参与者。2012年至2021年期间，MetS的未调整患病率从15.5%（95%CI：14.2%-16.8%）增至20.0%（95%CI：19.5%-20.5%）。在控制年龄和性别后，调整后的总体患病率从12.8%稳步上升至20.8%（P<0.001）。男性和年龄较大的人群MetS患病率更高。在MetS患病率、历年和城市人均GDP之间关联的回归模型中，历年与患病率呈正相关（P<0.001，95%CI：0.648-1.954），而城市人均GDP呈负相关（P=0.030，95%CI：-0.136至-0.007）。
2012-2021年期间，中国经济发达地区健康检查人群中MetS患病率稳步上升。研究人群中MetS患病率与人均GDP呈负相关。
